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Phenotype and function of protective T cell immune responses in HIV

Phenotype and function of protective T cell immune responses in HIV Phenotype and function of protective T cell immune responses in HIV a b Michael R. Betts and Alexandre Harari Department of Microbiology, University of Purpose of review Pennsylvania, Philadelphia, Pennsylvania, USA and b Definition of T cell immune correlates in HIV infection remains a lofty goal towards our Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of understanding of the HIV-specific immune response. This review will focus upon recent Medicine, Centre Hospitalier Universitaire Vaudois, developments and controversies in our understanding of protective T cell responses University of Lausanne, Lausanne, Switzerland against HIV. Correspondence to Michael R. Betts, Department of Recent findings Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA It has become clear that multiple functions and phenotypic markers of T cells must be Tel: +1 215 573 2773; þ þ assessed to accurately characterize the complexity of CD4 and CD8 T cell e-mail: betts@mail.med.upenn.edu responses. While evidence indicates that a hallmark of protective immune responses in HIV infection is the presence of ‘polyfunctional’ T cell responses, a disconnect remains Current Opinion in HIV and AIDS 2008, 3:349– between the function and phenotype of effective HIV-specific T cells. Moreover, there may be inherent differences in the ability http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Phenotype and function of protective T cell immune responses in HIV

Harari, Alexandre
Current Opinion in HIV and Aids , Volume 3 (3) – May 1, 2008
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References (76)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3282fbaa81
pmid
19372989
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Abstract

Phenotype and function of protective T cell immune responses in HIV a b Michael R. Betts and Alexandre Harari Department of Microbiology, University of Purpose of review Pennsylvania, Philadelphia, Pennsylvania, USA and b Definition of T cell immune correlates in HIV infection remains a lofty goal towards our Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of understanding of the HIV-specific immune response. This review will focus upon recent Medicine, Centre Hospitalier Universitaire Vaudois, developments and controversies in our understanding of protective T cell responses University of Lausanne, Lausanne, Switzerland against HIV. Correspondence to Michael R. Betts, Department of Recent findings Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA It has become clear that multiple functions and phenotypic markers of T cells must be Tel: +1 215 573 2773; þ þ assessed to accurately characterize the complexity of CD4 and CD8 T cell e-mail: betts@mail.med.upenn.edu responses. While evidence indicates that a hallmark of protective immune responses in HIV infection is the presence of ‘polyfunctional’ T cell responses, a disconnect remains Current Opinion in HIV and AIDS 2008, 3:349– between the function and phenotype of effective HIV-specific T cells. Moreover, there may be inherent differences in the ability

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2008

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