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M. Barathan, R. Mohamed, J. Vadivelu, L. Chang, Alireza Saeidi, Y. Yong, Ravishankar Mani, K. Gopal, V. Velu, M. Larsson, E. Shankar (2016)
Peripheral loss of CD8+CD161++TCRVα7·2+ mucosal‐associated invariant T cells in chronic hepatitis C virus‐infected patientsEuropean Journal of Clinical Investigation, 46
H. Vliet, B. Blomberg, M. Hazenberg, N. Nishi, S. Otto, B. Benthem, M. Prins, F. Claessen, A. Eertwegh, G. Giaccone, F. Miedema, R. Scheper, H. Pinedo (2002)
Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection.Journal of immunology, 168 3
C. Fernandez, T. Amarasena, A. Kelleher, J. Rossjohn, J. McCluskey, D. Godfrey, S. Kent (2015)
MAIT cells are depleted early but retain functional cytokine expression in HIV infectionImmunology and Cell Biology, 93
Sungyoo Cho, Kenneth Knox, Lisa Kohli, Johnny He, M. Exley, S. Wilson, R. Brutkiewicz (2005)
Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex.Virology, 337 2
C. Fernandez, A. Kelleher, R. Finlayson, D. Godfrey, S. Kent (2014)
NKT cell depletion in humans during early HIV infectionImmunology and Cell Biology, 92
A. Chan, Edwin Leeansyah, Edwin Leeansyah, Andrew Cochrane, Y. Acoz, D. Mittag, Leonard Harrison, D. Godfrey, S. Berzins, S. Berzins (2013)
Ex‐vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4+ and CD4− subsetsClinical & Experimental Immunology, 172
A. Zhen, Christopher Peterson, Mayra Carrillo, S. Reddy, Cindy Youn, Brianna Lam, Nelson Chang, Heather Martin, Jonathan Rick, Jennifer Kim, Nick Neel, V. Rezek, M. Kamata, I. Chen, J. Zack, H. Kiem, S. Kitchen (2017)
Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDSPLoS Pathogens, 13
B. Flach, P. Naluyima, K. Blom, V. Gonzalez, L. Eller, O. Laeyendecker, T. Quinn, D. Serwadda, N. Sewankambo, M. Wawer, R. Gray, N. Michael, F. Wabwire-mangen, M. Robb, M. Eller, J. Sandberg (2013)
Differential Loss of Invariant Natural Killer T Cells and FoxP3+ Regulatory T Cells in HIV-1 Subtype A and Subtype D InfectionsJAIDS Journal of Acquired Immune Deficiency Syndromes, 63
Mark Exley, Mark Exley, Mark Exley, P. Friedlander, N. Alatrakchi, L. Vriend, S. Yue, T. Sasada, Wanyong Zeng, Yo Mizukami, Justice Clark, David Nemer, K. Leclair, C. Canning, H. Daley, G. Dranoff, A. Giobbie-Hurder, F. Hodi, J. Ritz, S. Balk (2017)
Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical TrialClinical Cancer Research, 23
N. Chen, Corinna McCarthy, H. Drakesmith, Demin Li, V. Cerundolo, A. McMichael, G. Screaton, Xiao-ning Xu (2006)
HIV‐1 down‐regulates the expression of CD1d via NefEuropean Journal of Immunology, 36
C. Montoya, J. Cataño, Zoraida Ramírez, M. Rugeles, S. Wilson, A. Landay (2008)
Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype.Clinical immunology, 127 1
D. Singh, M. Ghate, S. Godbole, S. Kulkarni, M. Thakar (2017)
CD1d restricted Natural killer T cells are preserved in Indian long term non progressors (LTNPs).Journal of acquired immune deficiency syndromes
A. Zhen, Mayra Carrillo, S. Kitchen (2017)
Chimeric antigen receptor engineered stem cells: a novel HIV therapy.Immunotherapy, 9 5
M. Mureithi, Kristen Cohen, R. Moodley, D. Poole, Z. Mncube, A. Kasmar, D. Moody, P. Goulder, B. Walker, M. Altfeld, T. Ndung’u (2010)
Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.AIDS research and human retroviruses, 27 5
F. Ahmad, E. Shankar, Y. Yong, H. Tan, G. Ahrenstorf, R. Jacobs, M. Larsson, R. Schmidt, A. Kamarulzaman, A. Ansari (2017)
Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease ProgressionFrontiers in Immunology, 8
J. Eberhard, S. Kummer, P. Hartjen, A. Hüfner, T. Diedrich, O. Degen, A. Lohse, J. Lunzen, J. Wiesch (2016)
Reduced CD161+ MAIT cell frequencies in HCV and HIV/HCV co-infection: Is the liver the heart of the matter?Journal of hepatology, 65 6
Otto Yang, S. Wilson, L. Hultin, R. Detels, P. Hultin, F. Ibarrondo, Beth Jamieson (2007)
Delayed reconstitution of CD4+ iNKT cells after effective HIV type 1 therapy.AIDS research and human retroviruses, 23 7
N. Provine, B. Binder, M. FitzPatrick, A. Schuch, Lucy Garner, K. Williamson, B. Wilgenburg, R. Thimme, P. Klenerman, M. Hofmann (2018)
Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T CellsFrontiers in Immunology, 9
L. Bourhis, Yvonne Mburu, O. Lantz (2013)
MAIT cells, surveyors of a new class of antigen: development and functions.Current opinion in immunology, 25 2
A. Corbett, S. Eckle, R. Birkinshaw, Ligong Liu, O. Patel, J. Mahony, Zhenjun Chen, Rangsima Reantragoon, Bronwyn Meehan, H. Cao, N. Williamson, R. Strugnell, D. Sinderen, Jeffrey Mak, D. Fairlie, L. Kjer-Nielsen, J. Rossjohn, J. McCluskey (2014)
T-cell activation by transitory neo-antigens derived from distinct microbial pathwaysNature, 509
M. Salou, K. Franciszkiewicz, O. Lantz (2017)
MAIT cells in infectious diseases.Current opinion in immunology, 48
J. Sandberg, C. Stoddart, F. Brilot, K. Jordan, D. Nixon (2004)
Development of innate CD4+ α-chain variable gene segment 24 (Vα24) natural killer T cells in the early human fetal thymus is regulated by IL-7Proceedings of the National Academy of Sciences of the United States of America, 101
E. Chiappini, L. Betti, F. Bonsignori, C. Azzari, L. Galli, M. Martino (2010)
CD4+ and CD4− CD ID-Restricted Natural Killer T Cells in Perinatally HIV-1 Infected Children Receiving Highly Active Antiretroviral TherapyInternational Journal of Immunopathology and Pharmacology, 23
M. Spaan, S. Hullegie, Boris Beudeker, Kim Kreefft, G. Oord, Zwier Groothuismink, M. Tilborg, B. Rijnders, R. Knegt, M. Claassen, A. Boonstra (2016)
Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during TherapyPLoS ONE, 11
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Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infectionMucosal immunology, 10
A. Ma, R. Koka, P. Burkett (2006)
Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis.Annual review of immunology, 24
J. Eberhard, P. Hartjen, S. Kummer, R. Schmidt, M. Bockhorn, C. Lehmann, A. Balagopal, J. Hauber, J. Lunzen, Julian Wiesch (2014)
CD161+ MAIT Cells Are Severely Reduced in Peripheral Blood and Lymph Nodes of HIV-Infected Individuals Independently of Disease ProgressionPLoS ONE, 9
M. Moll, C. Kuylenstierna, V. Gonzalez, S. Andersson, L. Bosnjak, A. Sönnerborg, Maire Quigley, J. Sandberg (2009)
Severe functional impairment and elevated PD‐1 expression in CD1d‐restricted NKT cells retained during chronic HIV‐1 infectionEuropean Journal of Immunology, 39
F. Trottein, C. Paget (2018)
Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung InfectionsFrontiers in Immunology, 9
A. Rothchild, Pushpa Jayaraman, Cláudio Nunes-Alves, S. Behar (2014)
iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosisPLoS Pathogens, 10
This study provides key data on gut mucosal iNKT cells and their relationship to the gut microbiome in HIV-infected individuals
S. Vasan, M. Poles, A. Horowitz, E. Siladji, M. Markowitz, M. Tsuji (2007)
Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection.International immunology, 19 8
N. Provine, B. Binder, FitzPatrick Meb., A. Schuch, Lucy Garner, K. Williamson, B. Wilgenburg, R. Thimme, P. Klenerman, M. Hofmann (2018)
Unique and common features of innate-like human V[delta]2+ [gamma][delta]T cells and mucosal-associated invariant T cellsFrontiers in Immunology
W. Zou, J. Wolchok, Lieping Chen (2016)
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinationsScience Translational Medicine, 8
J. Booth, R. Salerno-Gonçalves, T. Blanchard, Seema Patil, H. Kader, Anca Safta, Lindsay Morningstar, S. Czinn, B. Greenwald, M. Sztein (2015)
Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori InfectionFrontiers in Immunology, 6
C. Cosgrove, J. Ussher, A. Rauch, K. Gärtner, A. Kurioka, M. Hühn, Krista Adelmann, Yu-Hoi Kang, J. Fergusson, P. Simmonds, P. Goulder, T. Hansen, J. Fox, H. Günthard, N. Khanna, F. Powrie, A. Steel, B. Gazzard, R. Phillips, J. Frater, H. Uhlig, P. Klenerman (2013)
Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.Blood, 121 6
R. Fleuridor, Brian Wilson, Runhua Hou, A. Landay, H. Kessler, L. Al-Harthi (2003)
CD1d‐restricted natural killer T cells are potent targets for human immunodeficiency virus infectionImmunology, 108
K. Benlagha, T. Kyin, A. Beavis, L. Teyton, A. Bendelac (2002)
A Thymic Precursor to the NK T Cell LineageScience, 296
Seung-Jung Kee, Yong-Soo Kwon, Yong-Wook Park, Young-Nan Cho, Sung-Ji Lee, Tae-Jong Kim, Shin-Seok Lee, H. Jang, M. Shin, Jong‐Hee Shin, S. Suh, D. Ryang (2012)
Dysfunction of Natural Killer T Cells in Patients with Active Mycobacterium tuberculosis InfectionInfection and Immunity, 80
T. Kufa, T. Mabuto, E. Muchiri, S. Charalambous, D. Rosillon, G. Churchyard, R. Harris (2014)
Incidence of HIV-Associated Tuberculosis among Individuals Taking Combination Antiretroviral Therapy: A Systematic Review and Meta-AnalysisPLoS ONE, 9
D. Godfrey, D. Godfrey, Adam Uldrich, Adam Uldrich, J. McCluskey, J. Rossjohn, J. Rossjohn, J. Rossjohn, D. Moody (2015)
The burgeoning family of unconventional T cellsNature Immunology, 16
J. Greene, S. Yue, D. O’Connor, R. Johnson, J. Else, M. Exley, N. Rout, D. O’Connor, A. Kaur (2012)
Loss of Effector and Anti-Inflammatory Natural Killer T Lymphocyte Function in Pathogenic Simian Immunodeficiency Virus InfectionPLoS Pathogens, 8
Andrew Hebbeler, Nadia Propp, C. Cairo, Haishan Li, Haishan Li, Jean-Saville Cummings, L. Jacobson, J. Margolick, C. Pauza (2008)
Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART).Clinical immunology, 128 3
I. Goping, M. Barry, P. Liston, T. Sawchuk, G. Constantinescu, Karolina Michalak, I. Shostak, D. Roberts, A. Hunter, Robert Korneluk, R. Bleackley (2003)
Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition.Immunity, 18 3
This study demonstrates the safety and clinical tolerability of iNKT cells as immunotherapy
H. Vliet, M. Vonderen, Johan Molling, H. Bontkes, M. Reijm, P. Reiss, M. Agtmael, S. Danner, A. Eertwegh, B. Blomberg, R. Scheper (2006)
Cutting Edge: Rapid Recovery of NKT Cells upon Institution of Highly Active Antiretroviral Therapy for HIV-1 Infection1The Journal of Immunology, 177
H. Vliet, B. Blomberg, M. Hazenberg, N. Nishi, S. Otto, B. Benthem, M. Prins, F. Claessen, A. Eertwegh, G. Giaccone, F. Miedema, R. Scheper, H. Pinedo (2002)
Selective Decrease in Circulating Vα24+Vβ11+ NKT Cells During HIV Type 1 Infection1The Journal of Immunology, 168
M. Zinser, A. Highton, A. Kurioka, B. Kronsteiner, Joachim Hagel, T. Leng, E. Marchi, Chansavath Phetsouphanh, C. Willberg, S. Dunachie, P. Klenerman (2018)
Human MAIT cells show metabolic quiescence with rapid glucose‐dependent upregulation of granzyme B upon stimulationImmunology and Cell Biology, 96
C. Crosby, M. Kronenberg (2018)
Tissue-specific functions of invariant natural killer T cellsNature Reviews Immunology, 18
L. Kjer-Nielsen, A. Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Mak, D. Godfrey, J. Rossjohn, D. Fairlie, J. McCluskey, S. Eckle (2018)
An overview on the identification of MAIT cell antigensImmunology and Cell Biology, 96
J. Sandberg, C. Stoddart, F. Brilot, K. Jordan, D. Nixon (2004)
Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7.Proceedings of the National Academy of Sciences of the United States of America, 101 18
Marielle Gold, S. Cerri, S. Smyk-Pearson, M. Cansler, T. Vogt, J. Delepine, Ervina Winata, Gwendolyn Swarbrick, Wei-Jen Chua, Y. Yu, O. Lantz, Matthew Cook, Megan Null, D. Jacoby, M. Harriff, D. Lewinsohn, T. Hansen, D. Lewinsohn (2010)
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected CellsPLoS Biology, 8
G. Galli, S. Nuti, Simona Tavarini, L. Galli‐Stampino, C. Lalla, G. Casorati, P. Dellabona, S. Abrignani (2003)
CD1d-restricted Help To B Cells By Human Invariant Natural Killer T LymphocytesThe Journal of Experimental Medicine, 197
J. Juno, Y. Keynan, K. Fowke (2012)
Invariant NKT Cells: Regulation and Function during Viral InfectionPLoS Pathogens, 8
G. Galli, P. Pittoni, Elena Tonti, Carmine Malzone, Y. Uematsu, Marco Tortoli, D. Maione, G. Volpini, O. Finco, S. Nuti, Simona Tavarini, P. Dellabona, R. Rappuoli, G. Casorati, S. Abrignani (2007)
Invariant NKT cells sustain specific B cell responses and memoryProceedings of the National Academy of Sciences, 104
S. Eckle, A. Corbett, A. Keller, Zhenjun Chen, D. Godfrey, Ligong Liu, Jeffrey Mak, D. Fairlie, J. Rossjohn, J. McCluskey (2015)
Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells*The Journal of Biological Chemistry, 290
Carol Vinton, Fan Wu, J. Rossjohn, K. Matsuda, J. McCluskey, V. Hirsch, D. Price, J. Brenchley (2016)
Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus MacaquesJournal of Virology, 90
J. Juno, A. Stalker, J. Waruk, J. Oyugi, M. Kimani, F. Plummer, J. Kimani, K. Fowke (2015)
Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatmentRetrovirology, 12
E. Leeansyah, A. Ganesh, Maire Quigley, A. Sönnerborg, J. Andersson, P. Hunt, M. Somsouk, S. Deeks, Jeffrey Martin, M. Moll, B. Shacklett, J. Sandberg (2013)
Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.Blood, 121 7
J. Fergusson, Kira Smith, V. Fleming, N. Rajoriya, E. Newell, Ruth Simmons, E. Marchi, S. Björkander, Yu-Hoi Kang, Leo Swadling, A. Kurioka, N. Sahgal, H. Lockstone, D. Baban, G. Freeman, E. Sverremark-Ekström, Mark Davis, M. Davenport, Vanessa Venturi, J. Ussher, C. Willberg, P. Klenerman (2014)
CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell LineagesCell Reports, 9
C. D’Souza, Zhenjun Chen, A. Corbett (2018)
Revealing the protective and pathogenic potential of MAIT cells.Molecular immunology, 103
N. Rout, J. Else, S. Yue, M. Connole, M. Exley, A. Kaur (2010)
Paucity of CD4+ Natural Killer T (NKT) Lymphocytes in Sooty Mangabeys Is Associated with Lack of NKT Cell Depletion after SIV InfectionPLoS ONE, 5
O. Sortino, Elizabeth Richards, Joana Dias, E. Leeansyah, J. Sandberg, I. Sereti (2018)
IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy.AIDS, 32 6
J. Snyder-Cappione, C. Loo, K. Carvalho, C. Kuylenstierna, S. Deeks, F. Hecht, M. Rosenberg, J. Sandberg, E. Kallas, D. Nixon (2009)
Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expressionAIDS, 23
Yaoxing Huang, Alex Chen, Xiangming Li, Zhiwei Chen, Wenyong Zhang, Yang Song, D. Gurner, D. Gardiner, S. Basu, D. Ho, M. Tsuji (2008)
Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide.Vaccine, 26 15
This is one of the only study to evaluate iNKT cells in LTNPs
C. Fernandez, A. Chan, K. Kyparissoudis, R. Rose, D. Godfrey, S. Kent (2008)
Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected MacaquesJournal of Virology, 83
E. Wong, N. Akilimali, P. Govender, Zuri Sullivan, C. Cosgrove, Mona Pillay, D. Lewinsohn, W. Bishai, B. Walker, T. Ndung’u, P. Klenerman, Victoria Kasprowicz (2013)
Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-InfectionPLoS ONE, 8
Shailbala Singh, Guojun Yang, S. Byrareddy, M. Barry, K. Sastry (2014)
Natural killer T cell and TLR9 agonists as mucosal adjuvants for sublingual vaccination with clade C HIV-1 envelope protein.Vaccine, 32 51
A. Kurioka, James Ussher, C. Cosgrove, C. Clough, J. Fergusson, Kira Smith, Yu-Hoi Kang, L. Walker, T. Hansen, C. Willberg, P. Klenerman (2014)
MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targetsMucosal Immunology, 8
H. Jeffery, B. Wilgenburg, A. Kurioka, K. Parekh, K. Stirling, S. Roberts, Emma Dutton, S. Hunter, D. Geh, M. Braitch, J. Rajanayagam, T. Iqbal, T. Pinkney, Rachel Brown, D. Withers, D. Adams, P. Klenerman, Y. Oo (2016)
Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1Journal of Hepatology, 64
Nacer-Eddine Serriari, M. Eoche, L. Lamotte, Julien Lion, M. Fumery, Paulo Marcelo, D. Chatelain, A. Barre, E. Nguyen-Khac, Olivier Lantz, J. Dupas, E. Treiner (2014)
Innate mucosal‐associated invariant T (MAIT) cells are activated in inflammatory bowel diseasesClinical & Experimental Immunology, 176
Dominic Paquin-Proulx, Anna Gibbs, S. Bächle, A. Checa, A. Introini, E. Leeansyah, C. Wheelock, D. Nixon, K. Broliden, Annelie Tjernlund, M. Moll, J. Sandberg (2016)
Innate Invariant NKT Cell Recognition of HIV-1–Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune EvasionThe Journal of Immunology, 197
Laurence Weiss, Mathieu Chevalier, L. Assoumou, C. Didier, Pierre-Marie Girard, Christophe Piketty, Dominique Costagliola, Christine Rouzioux (2014)
T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infectionAIDS, 28
E. Leeansyah, J. Svärd, Joana Dias, M. Buggert, J. Nyström, Maire Quigley, M. Moll, A. Sönnerborg, P. Nowak, J. Sandberg (2015)
Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 InfectionPLoS Pathogens, 11
M. Moll, S. Andersson, A. Smed-Sörensen, J. Sandberg (2010)
Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments.Blood, 116 11
S. Bächle, David Malone, M. Buggert, A. Karlsson, P. Isberg, Antonio Biague, H. Norrgren, P. Medstrand, M. Moll, J. Sandberg, M. Jansson (2016)
Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infectionsAIDS (London, England), 30
F. Ibarrondo, S. Wilson, L. Hultin, R. Shih, M. Hausner, P. Hultin, P. Anton, B. Jamieson, O. Yang (2012)
Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infectionMucosal Immunology, 6
D. Bollino, Tonya Webb (2017)
Chimeric antigen receptor-engineered natural killer and natural killer T cells for cancer immunotherapy.Translational research : the journal of laboratory and clinical medicine, 187
Amy Courtney, P. Nehete, B. Nehete, P. Thapa, Dapeng Zhou, K. Sastry (2009)
Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens.Vaccine, 27 25-26
M. Dhodapkar, Vipin Kumar (2017)
Type II NKT Cells and Their Emerging Role in Health and DiseaseThe Journal of Immunology, 198
O. Sortino, Elizabeth Richards, Joana Dias, E. Leeansyah, J. Sandberg, I. Sereti (2018)
IL-7 treatment supports CD8+ MAIT cell restoration in HIV-1 infected patients on ART.AIDS
Ruth Napier, E. Adams, Marielle Gold, D. Lewinsohn (2015)
The Role of Mucosal Associated Invariant T Cells in Antimicrobial ImmunityFrontiers in Immunology, 6
S. Biasi, E. Bianchini, M. Nasi, Margherita Digaetano, L. Gibellini, G. Carnevale, V. Borghi, G. Guaraldi, M. Pinti, C. Mussini, A. Cossarizza (2016)
Th1 and Th17 proinflammatory profile characterizes invariant natural killer T cells in virologically suppressed HIV+ patients with low CD4+/CD8+ ratioAIDS, 30
C. Fernandez, Sinthujan Jegaskanda, D. Godfrey, Stephen Kent (2013)
In‐vivo stimulation of macaque natural killer T cells with α‐galactosylceramideClinical & Experimental Immunology, 173
This is the first study to demonstrate an increase in MAIT cell frequency in HIVinfected patients because of a therapeutic intervention other than ART
J. Sandberg, N. Fast, Emil Palacios, G. Fennelly, J. Dobroszycki, P. Palumbo, A. Wiznia, R. Grant, N. Bhardwaj, M. Rosenberg, D. Nixon (2002)
Selective Loss of Innate CD4+ Vα24 Natural Killer T Cells in Human Immunodeficiency Virus InfectionJournal of Virology, 76
Greathead (2014)
CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on long-term antiretroviral therapy and correlate with CD8+ T-cell immune activationAIDS, 28
L. Walker, Yu-Hoi Kang, Matthew Smith, H. Tharmalingham, N. Ramamurthy, V. Fleming, N. Sahgal, Alistair Leslie, Y. Oo, A. Geremia, T. Scriba, W. Hanekom, G. Lauer, O. Lantz, D. Adams, F. Powrie, E. Barnes, P. Klenerman (2012)
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.Blood, 119 2
L. Loh, Zhongfang Wang, S. Sant, M. Koutsakos, Sinthujan Jegaskanda, A. Corbett, Ligong Liu, D. Fairlie, Jane Crowe, J. Rossjohn, Jianqing Xu, P. Doherty, J. McCluskey, K. Kedzierska (2016)
Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activationProceedings of the National Academy of Sciences, 113
Keli Holzapfel, A. Tyznik, M. Kronenberg, K. Hogquist (2014)
InfectionActivation of Invariant NKT Cells during Antigen-Dependent versus -Independent
D. Singh, M. Ghate, S. Godbole, S. Kulkarni, M. Thakar (2018)
Functional Invariant Natural Killer T Cells Secreting Cytokines Are Associated With Non-Progressive Human Immunodeficiency Virus-1 Infection but Not With Suppressive Anti-Retroviral TreatmentFrontiers in Immunology, 9
A. Heczey, Daofeng Liu, Gengwen Tian, Amy Courtney, Jie Wei, E. Marinova, Xiuhua Gao, Linjie Guo, E. Yvon, J. Hicks, Hao Liu, G. Dotti, L. Metelitsa (2014)
Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy.Blood, 124 18
Alison Motsinger, A. Azimzadeh, A. Stanic, R. Johnson, L. Kaer, S. Joyce, D. Unutmaz (2003)
Identification and Simian Immunodeficiency Virus Infection of CD1d-Restricted Macaque Natural Killer T CellsJournal of Virology, 77
F. Tilloy, E. Treiner, Se-Ho Park, Corinne Garcia, F. Lemonnier, H. Salle, A. Bendelac, M. Bonneville, O. Lantz (1999)
An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in MammalsThe Journal of Experimental Medicine, 189
R. Birkinshaw, L. Kjer-Nielsen, S. Eckle, J. McCluskey, J. Rossjohn (2014)
MAITs, MR1 and vitamin B metabolites.Current opinion in immunology, 26
K. Kawana, J. Matsumoto, S. Miura, Li Shen, Y. Kawana, T. Nagamatsu, T. Yasugi, T. Fujii, Huixia Yang, A. Quayle, Y. Taketani, D. Schust (2008)
Expression of CD1d and Ligand-Induced Cytokine Production Are Tissue Specific in Mucosal Epithelia of the Human Lower Reproductive TractInfection and Immunity, 76
B. Wilgenburg, Iris Scherwitzl, E. Hutchinson, T. Leng, A. Kurioka, Corinna Kulicke, C. Lara, S. Cole, Sirijitt Vasanawathana, W. Limpitikul, P. Malasit, D. Young, Laura Denney, Eleanor Guha, E. Barnes, J. Ball, Gary Burgess, G. Cooke, J. Dillon, C. Gore, G. Foster, Neil Guha, R. Halford, C. Herath, C. Holmes, A. Howe, E. Hudson, W. Irving, S. Khakoo, D. Koletzki, N. Martin, T. Mbisa, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, C. Spencer, P. Targett-Adams, E. Thomson, P. Vickerman, N. Zitzmann, M. Moore, P. Fabris, M. Giordani, Y. Oo, S. Laidlaw, L. Dustin, L. Ho, F. Thompson, N. Ramamurthy, J. Mongkolsapaya, C. Willberg, G. Screaton, P. Klenerman (2016)
MAIT cells are activated during human viral infectionsNature Communications, 7
Emmanuel Martin, E. Treiner, Livine Duban, L. Guerri, H. Laude, C. Toly, V. Prémel, A. Devys, I. Moura, F. Tilloy, Stéphane Cherif, Gabriella Vera, S. Latour, C. Soudais, O. Lantz (2009)
Stepwise Development of MAIT Cells in Mouse and HumanPLoS Biology, 7
Holzapfel (2014)
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Alison Motsinger, D. Haas, A. Stanic, L. Kaer, S. Joyce, D. Unutmaz (2002)
CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 InfectionThe Journal of Experimental Medicine, 195
Purpose of review To analyze the possible role that the ‘unconventional’ T-cell populations mucosal-associated invariant T cell (MAIT) and iNKT cells play during HIV infection and following antiretroviral therapy (ART) treatment. Recent findings A substantial body of evidence now demonstrates that both MAIT and iNKT cells are depleted in blood during HIV infection. The depletion and dysfunction of MAIT and iNKT cells are only partially restored by suppressive ART, potentially contributing to HIV-related comorbidities. Summary The deficiency and dysfunction of MAIT and iNKT T-cell subsets likely impact on immunity to important coinfections including Mycobacterium tuberculosis. This underscores the importance of research on restoring these unconventional T cells during HIV infection. Future studies in this field should address the challenge of studying tissue-resident cells, particularly in the gut, and better defining the determinants of MAIT/iNKT cell dysfunction. Such studies could have a significant impact on improving the immune function of HIV-infected individuals.
Current Opinion in HIV and AIDS – Wolters Kluwer Health
Published: Mar 1, 2019
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