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ORIGINAL ARTICLE Performance Status and Smoking Status Are Independent Favorable Prognostic Factors for Survival in Non-small Cell Lung Cancer A Comprehensive Analysis of 26,957 Patients with NSCLC Tomoya Kawaguchi, MD,* Minoru Takada, MD,* Akihito Kubo, MD,* Akihide Matsumura, MD,* Shimao Fukai, MD,† Atsuhisa Tamura, MD,‡ Ryusei Saito, MD,§ Yosihito Maruyama, PhD, Masaaki Kawahara, MD,* and Sai-Hong Ignatius Ou, MD, PhD¶ 0.990; p 0.0205), early stage, female gender, squamous cell Background: Performance status (PS) is an important factor in carcinoma histology, and treatment were all as independent determining survival outcome in non-small cell lung cancer favorable prognostic factors. (NSCLC) but is generally confounded by stage, age, gender, and Conclusions: PS and smoking status are independent prognostic smoking status. We investigated the prognostic significance of PS factors for OS in NSCLC. taking into account these important factors. Key Words: WHO performance status, Smoking status, Gender, Methods: Retrospective analysis of registry database of the National Prognostic factors, Non-small cell lung cancer, Histology, Cancer Hospital Study Group for Lung Cancer (NHSGLC) between1990 registry, National Hospital Study Group for Lung Cancer and 2005. Univariate analysis was performed using Kaplan-Meier (NHSGLC). method. Multivariate analysis was performed using Cox propor- tional hazards model to identify
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: May 1, 2010
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