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RESEARCH ARTICLE Performance Evaluation Comparison of 3 Commercially Available PCR-based KRAS Mutation Testing Platforms Julia A. Adams, MD, Kristin M. Post, MPH, Sarah A. Bilbo, BS, Xiaoyan Wang, MD, Joyashree D. Sen, MD, Anita J. Cornwell, BS, Amanda J. Malek, BS, and Liang Cheng, MD outcome and response to treatment in patients with ad- Abstract: The identification of KRAS mutations in patients with vanced-stage diseases such as colorectal and lung adeno- 1–4 certain types of cancer, including colonic adenocarcinoma and carcinoma. Targeted therapies for the epidermal growth non–small cell lung carcinoma, has become increasingly im- factor receptor (EGFR), such as the monoclonal antibodies portant as these patients are contraindicated from receiving cetuximab and panitumab, have improved prognosis in pa- epidermal growth factor receptor-targeted therapies. Several tients with both colorectal and lung adenocarcinoma. polymerase chain reaction (PCR)-based tests are commercially However, these therapies are only effective in patients lack- 5–10 available for KRAS mutation testing including Applied Bio- ing an activating mutation of the KRAS gene. Approx- systems KRAS Mutation Analysis on the ABI3130xl, Qiagen imately 15% to 30% of lung and 15% to 40% of colorectal therascreen KRAS RGQ PCR on the Rotor-Gene Q MDx, and adenocarcinomas harbor the
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2014
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