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Peanut Oil Reduces Diet‐Induced Atherosclerosis in Cynomolgus Monkeys

Peanut Oil Reduces Diet‐Induced Atherosclerosis in Cynomolgus Monkeys The atherogenicity of dietary peanut oil (PO) was examined in cynomolgus monkeys fed semipurified diets for 15 months. Four groups of six monkeys were fed diets containing 0.22 mg/kcal (0.1&percnt;) cholesterol and 0&percnt;, 5&percnt;, 10&percnt;, or 20&percnt; PO. An additional group was fed 2.0&percnt; cholesterol and 20&percnt; PO to serve as a literature control. Increasing the concentration of PO in the diet was associated with significant decreases in total plasma cholesterol (p< 0.05) and the total/HDL cholesterol ratio (p< 0.05) and an increase in the terminal HDL cholesterol concentration (p< 0.05). Intimal thickness and composition were determined from cross sections of the thoracic aorta and the iliac and coronary arteries. Increasing dietary PO was associated with decreases in thickness (p< 0.005), lipid (p< 0.001), and smooth muscle cells (p< 0.005) in the aortic intima. Aortic intimal lipid was positively correlated with the ratio of total to HDL cholesterol (r2= 0.78, p< 0.05). Monkeys fed 2.0&percnt; cholesterol and 20&percnt; PO revealed extensive atherosclerosis in all three arterial sites compared with those of any other group. Whereas the dietary fat effect was most demonstrable in the aorta, dietary cholesterol had a greater effect on the iliac and coronary arteries than it did on the aorta. Under these circumstances, dietary PO was not atherogenic in cynomolgus monkeys when fed with a concentration of cholesterol equivalent to that consumed by humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Peanut Oil Reduces Diet&hyphen;Induced Atherosclerosis in Cynomolgus Monkeys

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Copyright
© 1986 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

The atherogenicity of dietary peanut oil (PO) was examined in cynomolgus monkeys fed semipurified diets for 15 months. Four groups of six monkeys were fed diets containing 0.22 mg/kcal (0.1&percnt;) cholesterol and 0&percnt;, 5&percnt;, 10&percnt;, or 20&percnt; PO. An additional group was fed 2.0&percnt; cholesterol and 20&percnt; PO to serve as a literature control. Increasing the concentration of PO in the diet was associated with significant decreases in total plasma cholesterol (p< 0.05) and the total/HDL cholesterol ratio (p< 0.05) and an increase in the terminal HDL cholesterol concentration (p< 0.05). Intimal thickness and composition were determined from cross sections of the thoracic aorta and the iliac and coronary arteries. Increasing dietary PO was associated with decreases in thickness (p< 0.005), lipid (p< 0.001), and smooth muscle cells (p< 0.005) in the aortic intima. Aortic intimal lipid was positively correlated with the ratio of total to HDL cholesterol (r2= 0.78, p< 0.05). Monkeys fed 2.0&percnt; cholesterol and 20&percnt; PO revealed extensive atherosclerosis in all three arterial sites compared with those of any other group. Whereas the dietary fat effect was most demonstrable in the aorta, dietary cholesterol had a greater effect on the iliac and coronary arteries than it did on the aorta. Under these circumstances, dietary PO was not atherogenic in cynomolgus monkeys when fed with a concentration of cholesterol equivalent to that consumed by humans.

Journal

ArteriosclerosisWolters Kluwer Health

Published: Sep 1, 1986

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