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RESEARCH ARTICLE INK4a p16 Expression in Invasive Vulvar Squamous Cell Carcinoma Barbara Tringler, MD, Christoph Grimm, MD, Grazyna Dudek, BS, Robert Zeillinger, PhD, Clemens Tempfer, MD, Paul Speiser, MD, Elmar Joura, MD, Alexander Reinthaller, MD, and Lukas A. Hefler, MD INK4a The carcinogenic pathways involving p16 have INK4a Abstract: p16 , a member of the INK4a family of cyclin- been thoroughly investigated. An infection with a high- 6–8 dependent kinase inhibitors, is known as a negative regulator of risk human papillomavirus (HPV) may lead to the INK4a cell cycle progression and differentiation. Although p16 integration of the HPV genome into the host’s cellular has been shown to be a promising biomarker for the detection of DNA and disrupts the HPV E1/E2 open reading cervical intraepithelial neoplasia, few data have been published frame. This will then result in the loss of functional E2, on vulvar cancer. Using immunohistochemistry, we evaluated which is a regulatory protein of the virally encoded E6 INK4a 9,10 the expression of p16 in 80 cases of invasive vulvar and E7 oncoproteins. These oncoproteins contribute squamous cell carcinoma. Results were correlated with clinico- to the malignant cellular transformation by interfering pathologic parameters and survival data to determine
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Sep 1, 2007
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