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p16 Immunohistochemistry as an Alternative Marker to Distinguish Atypical Lipomatous Tumor From Deep-seated Lipoma

p16 Immunohistochemistry as an Alternative Marker to Distinguish Atypical Lipomatous Tumor From... RESEARCH ARTICLE p16 Immunohistochemistry as an Alternative Marker to Distinguish Atypical Lipomatous Tumor From Deep-seated Lipoma Mai He, MD, PhD,* Seena Aisner, MD,* Joseph Benevenia, MD,w Francis Patterson, MD,w Hana Aviv, PhD,z and Meera Hameed, MD* slow-growing masses in the extremities and retroperito- Abstract: Atypical lipomatous tumor (ALT)/well-differentiated neum. ALT/WDLPS has a high propensity for local liposarcoma (WDLPS) is a locally aggressive malignant recurrence and a potential for malignant dedifferentiation. mesenchymal neoplasm, resembling ordinary lipoma in many Patients with ALT/WDLPS require careful evaluation, clinical aspects. This study investigates the value of expression of complete surgical excision when possible, and close clinical p16, an important cell cycle regulator, alone or in combination follow-up extending beyond 5 years. ALT/WDLPS resem- with MDM2, to distinguish the 2 entities. Fifty cases of bles ordinary lipoma on clinical, radiologic, and gross lipomatous neoplasms, with cytogenetic results, from 45 patients examination. These tumors can often be a diagnostic were collected from the archives in Department of Pathology, challenge owing to the sparse distribution of lipoblasts University of Medicine and Dentistry of New Jersey/New Jersey and rare atypical stromal cells on light microscopy. Medical School during 1998 to 2006. These include 18 cases of ALT/WDLPS is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

p16 Immunohistochemistry as an Alternative Marker to Distinguish Atypical Lipomatous Tumor From Deep-seated Lipoma

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181719223
pmid
18779733
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE p16 Immunohistochemistry as an Alternative Marker to Distinguish Atypical Lipomatous Tumor From Deep-seated Lipoma Mai He, MD, PhD,* Seena Aisner, MD,* Joseph Benevenia, MD,w Francis Patterson, MD,w Hana Aviv, PhD,z and Meera Hameed, MD* slow-growing masses in the extremities and retroperito- Abstract: Atypical lipomatous tumor (ALT)/well-differentiated neum. ALT/WDLPS has a high propensity for local liposarcoma (WDLPS) is a locally aggressive malignant recurrence and a potential for malignant dedifferentiation. mesenchymal neoplasm, resembling ordinary lipoma in many Patients with ALT/WDLPS require careful evaluation, clinical aspects. This study investigates the value of expression of complete surgical excision when possible, and close clinical p16, an important cell cycle regulator, alone or in combination follow-up extending beyond 5 years. ALT/WDLPS resem- with MDM2, to distinguish the 2 entities. Fifty cases of bles ordinary lipoma on clinical, radiologic, and gross lipomatous neoplasms, with cytogenetic results, from 45 patients examination. These tumors can often be a diagnostic were collected from the archives in Department of Pathology, challenge owing to the sparse distribution of lipoblasts University of Medicine and Dentistry of New Jersey/New Jersey and rare atypical stromal cells on light microscopy. Medical School during 1998 to 2006. These include 18 cases of ALT/WDLPS is

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2009

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