Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Brand, T. Eisele, U. Kreusel, M. Page, S. Page, M. Haas, A. Gerling, C. Kaltschmidt, F. Neumann, N. Mackman, P. Baeuerle, A. Walli, D. Neumeier (1997)
Dysregulation of Monocytic Nuclear Factor-κB by Oxidized Low-Density LipoproteinArteriosclerosis, Thrombosis, and Vascular Biology, 17
A. Baldwin (2001)
Series introduction: the transcription factor NF-kappaB and human disease.The Journal of clinical investigation, 107 1
D. Steinberg, S. Parthasarathy, T. Carew, J. Khoo, J. Witztum (1989)
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.The New England journal of medicine, 320 14
A. Sevanian, H. Hodis, Juliana Hwang, L. McLeod, H. Peterson (1995)
Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL.Journal of lipid research, 36 9
N. Mackman (2003)
How do oxidized phospholipids inhibit LPS signaling?Arteriosclerosis, thrombosis, and vascular biology, 23 7
M. Ares, B. Kallin, P. Eriksson, J. Nilsson (1995)
Oxidized LDL Induces Transcription Factor Activator Protein–1 but Inhibits Activation of Nuclear Factor–κB in Human Vascular Smooth Muscle CellsArteriosclerosis, Thrombosis, and Vascular Biology, 15
S. Janssens, R. Beyaert (2003)
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.Molecular cell, 11 2
T. Hamilton, J. Major, D. Armstrong, J. Tebo (1998)
Oxidized LDL modulates activation of NFkappaB in mononuclear phagocytes by altering the degradation if IkappaBs.Journal of leukocyte biology, 64 5
R. Shackelford, U. Misra, K. Florine‐Casteel, S. Thai, S. Pizzo, D. Adams (1995)
Oxidized Low Density Lipoprotein Suppresses Activation of NFκB in Macrophages via a Pertussis Toxin-sensitive Signaling Mechanism (*)The Journal of Biological Chemistry, 270
F. Parhami, Z. Fang, A. Fogelman, A. Andalibi, M. Territo, J. Berliner (1993)
Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.The Journal of clinical investigation, 92 1
K. Brand, T. Eisele, U. Kreusel, M. Page, S. Page, M. Haas, A. Gerling, C. Kaltschmidt, F. Neumann, N. Mackman, P. Baeurele, A. Walli, D. Neumeier (1997)
Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein.Arteriosclerosis, thrombosis, and vascular biology, 17 10
T. Rajavashisth, H. Yamada, N. Mishra (1995)
Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL : involvement of nuclear factor-κBArteriosclerosis, Thrombosis, and Vascular Biology, 15
R. Lerner, A. Eschenmoser (2003)
Ozone in biologyProceedings of the National Academy of Sciences of the United States of America, 100
Guoqing Chen, D. Goeddel (2002)
TNF-R1 Signaling: A Beautiful PathwayScience, 296
J. Marx (2003)
Ozone May Be Secret Ingredient in Plaques' Inflammatory StewScience, 302
P. Wentworth, J. McDunn, A. Wentworth, Cindy Takeuchi, J. Nieva, T. Jones, C. Bautista, J. Ruedi, Abel Gutierrez, K. Janda, B. Babior, A. Eschenmoser, R. Lerner (2002)
Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and InflammationScience, 298
J. Gumulka, Leland Smith (1983)
Ozonization of cholesterolJournal of the American Chemical Society, 105
S. Page, C. Fischer, B. Baumgartner, M. Haas, U. Kreusel, G. Loidl, M. Hayn, H. Ziegler-Heitbrock, D. Neumeier, K. Brand (1999)
4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis*The Journal of Biological Chemistry, 274
M. Kałużny, L. Duncan, M. Merritt, D. Epps (1985)
Rapid separation of lipid classes in high yield and purity using bonded phase columns.Journal of lipid research, 26 1
Hai-bing Peng, T. Rajavashisth, P. Libby, J. Liao (1995)
Nitric Oxide Inhibits Macrophage-Colony Stimulating Factor Gene Transcription in Vascular Endothelial Cells (*)The Journal of Biological Chemistry, 270
S. Page, C. Fischer, B. Baumgartner, M. Haas, U. Kreusel, G. Loidl, M. Hayn, H. Ziegler-Heitbrock, D. Neumeier, K. Brand (1999)
4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis.The Journal of biological chemistry, 274 17
A. Baldwin (2001)
Series Introduction: The transcription factor NF-κB and human diseaseJournal of Clinical Investigation, 107
C. Glass, J. Witztum (2001)
Atherosclerosis The Road AheadCell, 104
J. Frostegård (2005)
Atherosclerosis in Patients With Autoimmune DisordersArteriosclerosis, Thrombosis, and Vascular Biology, 25
C. Hirschberg (2001)
Golgi nucleotide sugar transport and leukocyte adhesion deficiency IIJournal of Clinical Investigation, 108
T. Hamilton, J. Major, D. Armstrong, J. Tebo (1998)
Oxidized LDL modulates activation of NFκB in mononuclear phagocytes by altering the degradation of IκBsJournal of Leukocyte Biology, 64
P. Tobias, L. Curtiss (2005)
Thematic review series: The Immune System and Atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis Published, JLR Papers in Press, January 16, 2005. DOI 10.1194/jlr.R400015-JLR200Journal of Lipid Research, 46
(2002)
Missing pieces in the NF-kappaB
Xueyong Zhu, P. Wentworth, A. Wentworth, A. Eschenmoser, R. Lerner, I. Wilson (2004)
Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.Proceedings of the National Academy of Sciences of the United States of America, 101 8
G. Hansson, P. Libby, U. Schönbeck, Zhong‐qun Yan (2002)
Innate and Adaptive Immunity in the Pathogenesis of AtherosclerosisCirculation Research: Journal of the American Heart Association, 91
K. Brand, S. Page, G. Rogler, Armin Bartsch, Richard Brandl, R. Knuechel, M. Page, C. Kaltschmidt, P. Baeuerle, D. Neumeier (1996)
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.The Journal of clinical investigation, 97 7
B. Ohlsson, M. Englund, A. Karlsson, Ellen Knutsen, Cecilia Erixon, H. Skribeck, Yani Liu, G. Bondjers, O. Wiklund (1996)
Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages.The Journal of clinical investigation, 98 1
P. Wentworth, J. Nieva, Cindy Takeuchi, R. Galve, A. Wentworth, R. Dilley, G. Delaria, A. Saven, B. Babior, K. Janda, A. Eschenmoser, R. Lerner (2003)
Evidence for Ozone Formation in Human Atherosclerotic ArteriesScience, 302
V. Bochkov, A. Kadl, J. Huber, F. Gruber, B. Binder, N. Leitinger (2002)
Protective role of phospholipid oxidation products in endotoxin-induced tissue damageNature, 419
M. Quirling, S. Page, N. Jilg, Katharina Plenagl, D. Peus, Christine Grubmüller, Monika Weingärtner, C. Fischer, D. Neumeier, K. Brand (2004)
Detection of IKKβ-IKKγ Subcomplexes in Monocytic Cells and Characterization of Associated Signaling*Journal of Biological Chemistry, 279
M. Quirling, S. Page, N. Jilg, Katharina Plenagl, D. Peus, Christine Grubmüller, Monika Weingärtner, C. Fischer, D. Neumeier, K. Brand (2004)
Detection of IKKbeta-IKKgamma subcomplexes in monocytic cells and characterization of associated signaling.The Journal of biological chemistry, 279 36
Seppo Ylä-Herttuala (1998)
Is oxidized low-density lipoprotein present in vivo?Current opinion in lipidology, 9 4
Ozonized Low Density Lipoprotein (ozLDL) Inhibits NF-B and IRAK-1–Associated Signaling Christian Cappello, Bernd Saugel, Karin C. Huth, Andreas Zwergal, Martina Krautkra¨mer, Christophe Furman, Mustapha Rouis, Bianca Wieser, Heike W. Schneider, Dieter Neumeier, Korbinian Brand Objective—Recent studies have provided strong evidence for the presence of ozone in atherosclerotic lesions. In addition, modification of LDL has been suggested to be involved in atherosclerosis. In the present study we wanted to investigate whether LDL exposed to ozone (ozLDL) is able to modulate the NF-B system, as a paradigm for inflammatory signaling. Methods and Results—We showed that activation of NF-B by lipopolysaccharide (LPS), a prototypic inducer of innate immunity, was reversibly inhibited by ozLDL in monocytic THP-1 cells in a dose-dependent manner, whereas tumor necrosis factor (TNF) signaling was not affected. This was not attributable to a direct ozone effect or solely the presence of lipoprotein, and neither required direct contact to LPS nor was accompanied by a change in LPS binding. Comparable inhibitory effects of ozLDL were observed in human monocyte/macrophages and endothelial cells. The presence of ozLDL led to a decrease in LPS-induced I proteolysis and a reduction of B-dependent transcription/target-gene expression. Furthermore, ozLDL markedly lowered stimulus-induced I kinase (IKK) activity
Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health
Published: Jan 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.