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BASIC AND CLINICAL TRANSLATIONAL SCIENCE IN ALLERGY,ASTHMA AND IMMUNOLOGY 1 1 2,3 1 Umit M Sahiner, MD, Esra Birben, PhD, Serpil Erzurum, MD, Cansin Sackesen, MD, and Omer Kalayci, MD quinone oxidoreductase (NQO1), glutathione peroxidase, Abstract: Asthma is a chronic inflammatory lung disease that results 11 and glucuronosyltransferase-1a6 (UGT-1a6). At low level in airflow limitation, hyperreactivity, and airway remodeling. There of oxidative stress, antioxidants can restore cellular redox is strong evidence that an imbalance between the reducing and homeostasis. When high levels of oxidative stimuli are pres- oxidizing systems favoring a more oxidative state is present in ent, additional sets of intracellular signaling cascades are trig- asthma. Endogenous and exogenous reactive oxygen species, such as gered that are potentially proinflammatory. These include superoxide anion, hydroxyl radical, hypohalite radical, and hydrogen mitogen-activated protein kinase and nuclear factor-kB peroxide, and reactive nitrogen species, such as nitric oxide, (NF-kB), which lead to the expression of inflammatory cyto- peroxynitrite, and nitrite, play a major role in the airway kines, chemokines, and adhesion molecules. A further inflammation and are determinants of asthma severity. Asthma is increase in the level of oxidative stress could ultimately trig- also associated with decreased antioxidant defenses, such as ger
World Allergy Organization Journal – Wolters Kluwer Health
Published: Oct 1, 2011
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