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RESEARCH ARTICLE Overexpression of the avb6 Integrin in Endometrial Cancer Jonathan L. Hecht, MD, PhD,* Brian M. Dolinski,w Humphrey A. Gardner, MD,w Shelia M. Violette, PhD,w and Paul H. Weinreb, PhDw role in tumor proliferation, survival, invasion, and 3–7 Abstract: The alpha(v)beta(6) integrin (avb6) has been shown to metastasis. be up-regulated in adenocarcinoma of the breast, colon, avb6 has expression restricted to epithelial cells and stomach, and ovary, generally reflecting a more aggressive has been shown to be up-regulated in areas of wound 2,8,9 phenotype. Expression in endometrial cancer has not been healing and in neoplasms, including oral squamous reported. We analyzed avb6 expression in the tissue from carcinoma and adenocarcinomas of the breast, colon, primary endometrial carcinomas (endometrioid type) using a stomach, and ovary, generally reflecting a more aggres- 3,7,10–14 mouse monoclonal antibody against human avb6, and corre- sive phenotype. We used monoclonal antibodies lated the findings with grade, stage, and nodal involvement. specific for avb6 15 to evaluate expression in normal Normal cycling endometrium was studied for comparison. avb6 cycling endometrium and endometrial carcinoma in was only weakly expressed in normal epithelium and infre- relation to grade and stage. quently expressed in precancers, but up-regulated in the
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Dec 1, 2008
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