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T. Madhusudhan, Hongjie Wang, B. Straub, E. Gröne, Qianxing Zhou, K. Shahzad, S. Müller-Krebs, V. Schwenger, B. Gerlitz, B. Grinnell, J. Griffin, J. Reiser, H. Gröne, C. Esmon, P. Nawroth, B. Isermann (2012)
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H. Branson, R. Marble, J. Katz, JohnH. Griffin (1983)
INHERITED PROTEIN C DEFICIENCY AND COUMARIN-RESPONSIVE CHRONIC RELAPSING PURPURA FULMINANS IN A NEWBORN INFANTThe Lancet, 322
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Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivoThrombosis and Haemostasis, 103
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Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus : Lack of Correlation With Thrombomodulin Suggests Involvement of Different Pathological Processes
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Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.The Journal of clinical investigation, 120 9
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B. Isermann, Ilya Vinnikov, T. Madhusudhan, S. Herzog, Muhammed Kashif, J. Blautzik, Marcus Corat, M. Zeier, E. Blessing, J. Oh, B. Gerlitz, D. Berg, B. Grinnell, T. Chavakis, C. Esmon, H. Weiler, A. Bierhaus, P. Nawroth (2007)
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Weihong Li, Xunzhen Zheng, J. Gu, Jerrod Hunter, G. Ferrell, F. Lupu, N. Esmon, C. Esmon (2005)
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxinJournal of Thrombosis and Haemostasis, 3
C. Feistritzer, M. Riewald (2005)
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M. Nagai, S. Terao, G. Yilmaz, C. Yilmaz, C. Esmon, E. Watanabe, D. Granger (2010)
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A. Drygalski, Christian Furlan-Freguia, L. Mosnier, S. Yegneswaran, W. Ruf, J. Griffin (2012)
Infrared fluorescence for vascular barrier breach in vivo – A novel method for quantitation of albumin effluxThrombosis and Haemostasis, 108
Jiaqiong Xu, Y. Ji, Xiaomei Zhang, M. Drake, C. Esmon, C. Esmon, C. Esmon (2009)
Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride‐induced septic shockJournal of Thrombosis and Haemostasis, 7
H. Yuda, Y. Adachi, O. Taguchi, E. Gabazza, O. Hataji, H. Fujimoto, S. Tamaki, K. Nishikubo, K. Fukudome, C. D'Alessandro-Gabazza, J. Maruyama, M. Izumizaki, M. Iwase, I. Homma, R. Inoue, H. Kamada, Tatsuya Hayashi, M. Kasper, B. Lambrecht, P. Barnes, Koji Suzuki (2004)
Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice.Blood, 103 6
A. Rezaie (2011)
The occupancy of endothelial protein C receptor by its ligand modulates the par‐1 dependent signaling specificity of coagulation proteasesIUBMB Life, 63
C. Feistritzer, B. Mosheimer, D. Sturn, M. Riewald, J. Patsch, C. Wiedermann (2006)
Endothelial Protein C Receptor-Dependent Inhibition of Migration of Human Lymphocytes by Protein C Involves Epidermal Growth Factor Receptor1The Journal of Immunology, 176
Organ-Specific Protection Against Lipopolysaccharide- Induced Vascular Leak Is Dependent on the Endothelial Protein C Receptor Annette von Drygalski, Christian Furlan-Freguia, Wolfram Ruf, John H. Griffin, Laurent O. Mosnier Objective—To study the role of the endothelial protein C receptor (EPCR) in the modulation of susceptibility to inflammation- induced vascular leak in vivo. low Approach and Results—Genetically modified mice with low, <10% EPCR expression (EPCR ) and control mice were challenged with lipopolysaccharides in a mouse model of endotoxemia. Infrared fluorescence and quantification of albumin-bound Evans Blue in tissues and intravascular plasma volumes were used to assess plasma extravasation. Pair- low wise analysis of EPCR and control mice matched for sex, age, and weight allowed determination of EPCR-dependent vascular leak. Kidney, lung, and brain were the organs with highest discriminative increased Evans Blue accumulation low in EPCR versus control mice in response to lipopolysaccharides. Histology of kidney and lung confirmed the EPCR- low specific pathology. In addition to severe kidney injury in response to lipopolysaccharides, EPCR and anti-EPCR– treated wild-type mice suffered from enhanced albuminuria and profound renal hemorrhage versus controls. Intravascular low volume loss at the same extent of weight loss in EPCR mice compared with control mice provided proof
Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health
Published: Apr 1, 2013
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