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Oncocytoma Can be Differentiated From its Renal Cell Carcinoma Mimics by a Panel of Markers An Automated Tissue Microarray Study

Oncocytoma Can be Differentiated From its Renal Cell Carcinoma Mimics by a Panel of Markers An... RESEARCH ARTICLE Oncocytoma Can be Differentiated From its Renal Cell Carcinoma Mimics by a Panel of Markers An Automated Tissue Microarray Study Wei Huang, MD,*w Kazunori Kanehira, MD,*w Sally Drew, BS,w and Thomas Pier, BS* (Appl Immunohistochem Mol Morphol 2009;17:12–17) Background: Differentiating oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation. This study presents a panel of markers that are readily available, easy to use, and useful for differential BACKGROUND diagnoses of renal tumors. The contemporary classification subdivides renal cell tumors into benign and malignant parenchymal Design: A renal cell neoplasm tissue microarray was constructed neoplasms. Benign tumors are subclassified into meta- including oncocytoma (n = 30), chromophobe RCC (n = 18), nephric adenoma and adenofibroma, papillary renal cell conventional RCC (n = 64), papillary RCC (n = 50), and adenoma, and renal oncocytoma. Malignant tumors are benign renal tissues (n = 31). CK7, CD10, epithelial membrane subclassified into conventional renal cell carcinoma antigen, renal cell carcinoma marker (RCCma), vimentin, and (RCC), papillary RCC, chromophobe RCC, collecting endogenous avidin-binding activity (EABA) were studied. An duct carcinoma, medullary carcinoma of the kidney, and Automated Cellular Imaging System, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Oncocytoma Can be Differentiated From its Renal Cell Carcinoma Mimics by a Panel of Markers An Automated Tissue Microarray Study

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e318173e79d
pmid
18769342
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Oncocytoma Can be Differentiated From its Renal Cell Carcinoma Mimics by a Panel of Markers An Automated Tissue Microarray Study Wei Huang, MD,*w Kazunori Kanehira, MD,*w Sally Drew, BS,w and Thomas Pier, BS* (Appl Immunohistochem Mol Morphol 2009;17:12–17) Background: Differentiating oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation. This study presents a panel of markers that are readily available, easy to use, and useful for differential BACKGROUND diagnoses of renal tumors. The contemporary classification subdivides renal cell tumors into benign and malignant parenchymal Design: A renal cell neoplasm tissue microarray was constructed neoplasms. Benign tumors are subclassified into meta- including oncocytoma (n = 30), chromophobe RCC (n = 18), nephric adenoma and adenofibroma, papillary renal cell conventional RCC (n = 64), papillary RCC (n = 50), and adenoma, and renal oncocytoma. Malignant tumors are benign renal tissues (n = 31). CK7, CD10, epithelial membrane subclassified into conventional renal cell carcinoma antigen, renal cell carcinoma marker (RCCma), vimentin, and (RCC), papillary RCC, chromophobe RCC, collecting endogenous avidin-binding activity (EABA) were studied. An duct carcinoma, medullary carcinoma of the kidney, and Automated Cellular Imaging System,

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2009

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