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Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy

Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy Ventricular Structure and Function Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy Oliver J. Rider, BMBCh, DPhil; Andrew J.M. Lewis, MBBS, MRes; Adam J. Lewandowski, BSc, DPhil; Ntobeko Ntusi, DPhil; Richard Nethononda, DPhil; Steffen E. Petersen, MD, DPhil; Jane M. Francis, DCR, DNM; Alex Pitcher, BMBCh, DPhil; Rajarshi Banerjee, BMBCh, DPhil; Paul Leeson, PhD; Stefan Neubauer, MD Background—As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy. Methods and Results—Seven hundred thirty-nine subjects (women, n=345; men, n=394) without identifiable cardiovascular risk factors (body mass index [BMI], 15.3–59.2 kg/m ) underwent cardiovascular magnetic resonance (1.5 T) to measure RV mass (g), RV end-diastolic volume (mL), RV mass/volume ratio, and LV diastolic peak filling rate (mL/s). All subjects were normotensive (average, 119±11/73±8 mm Hg), normoglycaemic (4.8±0.5 mmol/L), and normocholesterolaemic (4.8±0.9 mmol/L) at the time of scanning. Across both sexes, there was a moderately strong positive correlation between BMI and RV mass (men, +0.8 g per BMI point increase; women, +1.0 g http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy

Circulation: Cardiovascular Imaging , Volume 8 (1) – Jan 1, 2015

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References (33)

Copyright
© 2014 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.114.002454
pmid
25552492
Publisher site
See Article on Publisher Site

Abstract

Ventricular Structure and Function Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy Oliver J. Rider, BMBCh, DPhil; Andrew J.M. Lewis, MBBS, MRes; Adam J. Lewandowski, BSc, DPhil; Ntobeko Ntusi, DPhil; Richard Nethononda, DPhil; Steffen E. Petersen, MD, DPhil; Jane M. Francis, DCR, DNM; Alex Pitcher, BMBCh, DPhil; Rajarshi Banerjee, BMBCh, DPhil; Paul Leeson, PhD; Stefan Neubauer, MD Background—As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy. Methods and Results—Seven hundred thirty-nine subjects (women, n=345; men, n=394) without identifiable cardiovascular risk factors (body mass index [BMI], 15.3–59.2 kg/m ) underwent cardiovascular magnetic resonance (1.5 T) to measure RV mass (g), RV end-diastolic volume (mL), RV mass/volume ratio, and LV diastolic peak filling rate (mL/s). All subjects were normotensive (average, 119±11/73±8 mm Hg), normoglycaemic (4.8±0.5 mmol/L), and normocholesterolaemic (4.8±0.9 mmol/L) at the time of scanning. Across both sexes, there was a moderately strong positive correlation between BMI and RV mass (men, +0.8 g per BMI point increase; women, +1.0 g

Journal

Circulation: Cardiovascular ImagingWolters Kluwer Health

Published: Jan 1, 2015

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