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Haeryoung Kim, Jeong-Eun Yoo, J. Cho, Bong-Kyeong Oh, Yoo-Seok Yoon, Ho-Seong Han, H. Lee, Ja-june Jang, S. Jeong, Jin Kim, Y. Park (2013)
Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing "stemness"-related markers.Journal of hepatology, 59 4
M. Sobrinho-Simões, V. Gonçalves, F. Sousa-Lé, V. Cardoso (1977)
A morphometric study of nuclei, nucleoli and nuclear bodies in goitres and papillary thyroid carcinomasExperientia, 33
(2012)
The nucleolar detention pathway: a cellular strategy for regulating molecular networks
J. Wong, L. Kusdra, K. Collins (2002)
Subnuclear shuttling of human telomerase induced by transformation and DNA damageNature Cell Biology, 4
E. Burns, B. Soloff, C. Hamma, D. Buxton (1971)
Nuclear pockets associated with the nucleolus in normal and neoplastic cells.Cancer research, 31 2
LETTER TO THE EDITOR Nucleolar Cytokeratin 19 in Thyroid Carcinoma To the Editor: Immunohistochemical features of nucleoli in thyroid nodules are rarely reported. We had the opportunity to study on microscopy papillary thyroid carcinoma cells for cytokeratin (CK)19 immunohistochemical expression on tissue sections. Besides the classic cy- toplasmic diffuse expression, consid- ered an important diagnostic element FIGURE 1. Cytokeratin 19 was expressed in a nucleolar dot-like pattern in papillary for thyroid carcinomas, the CK19 thyroid carcinoma cells (arrow shows nucleolar staining). Original magnification 100. showed also an intranuclear dot-pat- terned expression in several tumor cells (Fig. 1). This intranuclear dot-like depletion (as compared with the nu- ACKNOWLEDGMENTS expression pattern suggested rather a cleoplasm) in the late S/G2-phase. The authors thank the NCA/Avic- nucleolar detention mechanism for In conclusion, our observation enne,CDMP/APHP,and theBIUM CK19 than the presence of a nuclear suggests the presence of CK19-related teams. 1–3 cytoplasmic pocket/inclusion-type. nucleolar detention pathway in pap- The intranuclear redistribution of this illary thyroid carcinoma cells as sug- acidic cytokeratin (OMIM 148020), gested by the presence of a nucleolar REFERENCES protein normally located in the cell expression. Further studies are re- 1. Audas TE, Jacob MD, Lee S. The nucleolar cytoplasm, is consistent with the func- quired to decipherate the background detention pathway: a cellular strategy for tioning of a nucleolar detention path- regulating molecular networks. Cell Cycle. and relevance of nucleolar changes in way. The pathogenesis of this change is 2012;11:2059–2062. tumor pathology. 2. Burns ER, Soloff BL, Hamma C, et al. difficult to explain, rather related to Nuclear pockets associated with the nucleo- intratumor acidosis than to other lus in normal and neoplastic cells. Cancer known causes of nucleolar detention Res. 1971;31:159–165. such as heat shock or transcriptional 3. Sobrinho-Simo˜ es MA, Gonc¸alves V, Sousa- stress. To note would be the fact that Le´ F, et al. A morphometric study of nuclei, nucleoli and nuclear bodies in goitres and TERT, a putative nucleolar detention Adriana Handra-Luca, MD, PhD* papillary thyroid carcinomas. Experientia. signaling protein that is frequently ex- 1977;33:1642–1643. Frederique Tissier, MD, PhDw pressed in hepatocellular carcinomas 4. Kim H, Yoo JE, Cho JY, et al. Telomere length, *APHP GHU Avicena, Paris Nord expressing the stemness marker CK19, TERT and shelterin complex proteins in hep- Sorbonne Cite University atocellular carcinomas expressing “stemness” can undergo stimuli-induced “sequest- Bobigny, France related markers. J Hepatol. 2013;59:746–752. ration” within the nucleolus. This wAPHP University Hospital Pitie´ - 5. Wong JM, Kusdra L, Collins K. Subnuclear process is cell-cycle dependent in nor- Salpetriere, Pierre and Marie Curie shuttling of human telomerase induced by mal cells, featuring prominent nucleo- Sorbonne University transformation and DNA damage. Nat Cell lus in the G1-phase and, nucleolar Paris, France Biol. 2002;4:731–736. The authors declare no conflict of interest. Appl Immunohistochem Mol Morphol Volume 25, Number 5, May/June 2017 www.appliedimmunohist.com e37 Copyright r 2017 Wolters Kluwer Health, Inc. All rights reserved.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jun 2, 2016
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