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Nuclear β-Catenin Expression Is Rare and its Potential Association With Short Survival in Colorectal Signet-Ring Cell Carcinoma

Nuclear β-Catenin Expression Is Rare and its Potential Association With Short Survival in... RESEARCH Nuclear b-Catenin Expression Is Rare and its Potential Association With Short Survival in Colorectal Signet-Ring Cell Carcinoma S. C. C. Wong, PhD,* A. T. C. Chan, MD, FRCP,* E. S. F. Lo, MPhil,† and Y. M. D. Lo, MD, PhD‡ around 30 months. Apart from these data, the clinicopath- Abstract: Colorectal signet-ring cell carcinoma (SRCC) is a rare ological features remain controversial. Moreover, the biologic cancer and the prognosis is usually very poor. The biologic pathways pathways involved in the oncogenesis of this tumor are involved in its oncogenesis are unknown. b-catenin, a key target in unknown. Such information, if available, might eventually im- the Wnt-signaling pathway, is recognized to play an important role in prove patient outcome. the carcinogenesis in conventional colorectal carcinoma. This study b-catenin was first identified as a protein associated with explores the involvement of Wnt-signaling molecules b-catenin and E-cadherin in maintaining cell–cell interactions. Under nor- cyclin D1, cell cycle regulators cyclin D3, proliferative index Ki-67, mal situations, b-catenin is under the rigorous control of the 5,6 apoptotic index, and angiogenic indicator CD31 in 20 colorectal upstream regulators in the Wnt-signaling cascade through SRCC paraffin-embedded specimens. Results showed that there were degradation by interaction http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Nuclear β-Catenin Expression Is Rare and its Potential Association With Short Survival in Colorectal Signet-Ring Cell Carcinoma

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References (18)

Copyright
Copyright © 2005 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/01.pai.0000142845.91862.c8
Publisher site
See Article on Publisher Site

Abstract

RESEARCH Nuclear b-Catenin Expression Is Rare and its Potential Association With Short Survival in Colorectal Signet-Ring Cell Carcinoma S. C. C. Wong, PhD,* A. T. C. Chan, MD, FRCP,* E. S. F. Lo, MPhil,† and Y. M. D. Lo, MD, PhD‡ around 30 months. Apart from these data, the clinicopath- Abstract: Colorectal signet-ring cell carcinoma (SRCC) is a rare ological features remain controversial. Moreover, the biologic cancer and the prognosis is usually very poor. The biologic pathways pathways involved in the oncogenesis of this tumor are involved in its oncogenesis are unknown. b-catenin, a key target in unknown. Such information, if available, might eventually im- the Wnt-signaling pathway, is recognized to play an important role in prove patient outcome. the carcinogenesis in conventional colorectal carcinoma. This study b-catenin was first identified as a protein associated with explores the involvement of Wnt-signaling molecules b-catenin and E-cadherin in maintaining cell–cell interactions. Under nor- cyclin D1, cell cycle regulators cyclin D3, proliferative index Ki-67, mal situations, b-catenin is under the rigorous control of the 5,6 apoptotic index, and angiogenic indicator CD31 in 20 colorectal upstream regulators in the Wnt-signaling cascade through SRCC paraffin-embedded specimens. Results showed that there were degradation by interaction

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Sep 1, 2005

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