Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

NR4A Orphan Nuclear Receptors Transcriptional Regulators of Gene Expression in Metabolism and Vascular Biology

NR4A Orphan Nuclear Receptors Transcriptional Regulators of Gene Expression in Metabolism and... ATVB in Focus Nuclear Receptors in Metabolism and Cardiovascular Disease Series Editor: Bart Staels NR4A Orphan Nuclear Receptors Transcriptional Regulators of Gene Expression in Metabolism and Vascular Biology Yue Zhao, Dennis Bruemmer Abstract—Members of the nuclear hormone receptor superfamily, including the peroxisome proliferator–activated receptor and the liver X receptor subfamilies, orchestrate transcriptional networks involved in the control of metabolism and the development of vascular disease. In addition to these well-characterized ligand-activated transcription factors, the nuclear receptor (NR) superfamily comprises many orphan receptors, whose ligands and physiological functions remain unknown. Among this group of orphan receptors is the NR4A subfamily, including Nur77 (NR4A1), Nurr1 (NR4A2), and NOR1 (NR4A3). These orphan NRs constitute an evolutionary ancient and highly conserved group of transcription factors. In contrast to other members of the superfamily, NR4A receptors function as ligand-independent transcription factors and immediate- or early-response genes, which are rapidly induced by a pleiotropy of environmental cues. Early functional studies have pointed to a critical role of NR4A receptors in regulating differentiation, proliferation, and apoptosis. More recent research has characterized NR4A receptors as key transcriptional regulators of glucose and lipid homeostasis, adipogenesis, inflammation, and vascular remodeling. In this review, we will summarize recent advances in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

NR4A Orphan Nuclear Receptors Transcriptional Regulators of Gene Expression in Metabolism and Vascular Biology

Loading next page...
 
/lp/wolters-kluwer-health/nr4a-orphan-nuclear-receptors-transcriptional-regulators-of-gene-AuD060cvTU

References (91)

ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.109.191163
pmid
20631354
Publisher site
See Article on Publisher Site

Abstract

ATVB in Focus Nuclear Receptors in Metabolism and Cardiovascular Disease Series Editor: Bart Staels NR4A Orphan Nuclear Receptors Transcriptional Regulators of Gene Expression in Metabolism and Vascular Biology Yue Zhao, Dennis Bruemmer Abstract—Members of the nuclear hormone receptor superfamily, including the peroxisome proliferator–activated receptor and the liver X receptor subfamilies, orchestrate transcriptional networks involved in the control of metabolism and the development of vascular disease. In addition to these well-characterized ligand-activated transcription factors, the nuclear receptor (NR) superfamily comprises many orphan receptors, whose ligands and physiological functions remain unknown. Among this group of orphan receptors is the NR4A subfamily, including Nur77 (NR4A1), Nurr1 (NR4A2), and NOR1 (NR4A3). These orphan NRs constitute an evolutionary ancient and highly conserved group of transcription factors. In contrast to other members of the superfamily, NR4A receptors function as ligand-independent transcription factors and immediate- or early-response genes, which are rapidly induced by a pleiotropy of environmental cues. Early functional studies have pointed to a critical role of NR4A receptors in regulating differentiation, proliferation, and apoptosis. More recent research has characterized NR4A receptors as key transcriptional regulators of glucose and lipid homeostasis, adipogenesis, inflammation, and vascular remodeling. In this review, we will summarize recent advances in

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Aug 1, 2010

There are no references for this article.