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Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification

Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification Selection of patients for abdominal aortic aneurysm repair is currently based on aneurysm size, growth rate, and symptoms. Molecular imaging of biological processes associated with aneurysm growth and rupture, for example, inflammation and matrix remodeling, could improve patient risk stratification and lead to a reduction in abdominal aortic aneurysm morbidity and mortality. 18 F-fluorodeoxyglucose-positron emission tomography and ultrasmall superparamagnetic particles of iron oxide magnetic resonance imaging are 2 novel approaches to abdominal aortic aneurysm imaging evaluated in clinical trials. A variety of other tracers, including those that target inflammatory cells and proteolytic enzymes (eg, integrin α v β 3 and matrix metalloproteinases), have proven effective in preclinical models of abdominal aortic aneurysm and show great potential for clinical translation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification

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References (63)

Publisher
Wolters Kluwer Health
Copyright
© 2016 American Heart Association, Inc.
Subject
10012; 10129; 10130; 10132; 10185; Advances in Cardiovascular Imaging
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.115.003023
pmid
26763279
Publisher site
See Article on Publisher Site

Abstract

Selection of patients for abdominal aortic aneurysm repair is currently based on aneurysm size, growth rate, and symptoms. Molecular imaging of biological processes associated with aneurysm growth and rupture, for example, inflammation and matrix remodeling, could improve patient risk stratification and lead to a reduction in abdominal aortic aneurysm morbidity and mortality. 18 F-fluorodeoxyglucose-positron emission tomography and ultrasmall superparamagnetic particles of iron oxide magnetic resonance imaging are 2 novel approaches to abdominal aortic aneurysm imaging evaluated in clinical trials. A variety of other tracers, including those that target inflammatory cells and proteolytic enzymes (eg, integrin α v β 3 and matrix metalloproteinases), have proven effective in preclinical models of abdominal aortic aneurysm and show great potential for clinical translation.

Journal

Circulation: Cardiovascular ImagingWolters Kluwer Health

Published: Jan 1, 2016

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