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Novel mechanisms of HIV protease inhibitor resistance

Novel mechanisms of HIV protease inhibitor resistance a a b Monique Nijhuis , Noortje M. van Maarseveen , Jens Verheyen and a,c Charles A.B. Boucher Department of Medical Microbiology, University Purpose of review Medical Center Utrecht, Utrecht, The Netherlands, b Several alternative mechanisms that cause protease inhibitor resistance have been Institute of Virology, University of Cologne, Cologne, Germany and Department of Virology, Erasmus proposed. A summary of the proposed mechanisms and the status regarding their Medical Center, Rotterdam, The Netherlands clinical relevance is given. Correspondence to Charles Boucher, Department of Recent findings Medical Microbiology, University Medical Center At this moment only changes in the cleavage sites of protease (either alone or in the Utrecht, Heidelberglaan 100 (HP G04.614), 3584 CX Utrecht, The Netherlands background of protease mutations) have been associated with phenotypic changes in Tel: +31 88 755 6526; fax: +31 88 755 5426; IC and virological failure. e-mail: c.boucher@umcutrecht.nl Summary Current Opinion in HIV and AIDS 2008, 3:627– Further studies are necessary to unravel the mechanism, the clinical relevance and potential effect of transmission of these cleavage site changes. Keywords Gag cleavage sites, protease inhibitor therapy, resistance Curr Opin HIV AIDS 3:627–632 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins 1746-630X in which all http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Novel mechanisms of HIV protease inhibitor resistance

Boucher, Charles AB
Current Opinion in HIV and Aids , Volume 3 (6) – Nov 1, 2008
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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3283136cd9
pmid
19373034
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Abstract

a a b Monique Nijhuis , Noortje M. van Maarseveen , Jens Verheyen and a,c Charles A.B. Boucher Department of Medical Microbiology, University Purpose of review Medical Center Utrecht, Utrecht, The Netherlands, b Several alternative mechanisms that cause protease inhibitor resistance have been Institute of Virology, University of Cologne, Cologne, Germany and Department of Virology, Erasmus proposed. A summary of the proposed mechanisms and the status regarding their Medical Center, Rotterdam, The Netherlands clinical relevance is given. Correspondence to Charles Boucher, Department of Recent findings Medical Microbiology, University Medical Center At this moment only changes in the cleavage sites of protease (either alone or in the Utrecht, Heidelberglaan 100 (HP G04.614), 3584 CX Utrecht, The Netherlands background of protease mutations) have been associated with phenotypic changes in Tel: +31 88 755 6526; fax: +31 88 755 5426; IC and virological failure. e-mail: c.boucher@umcutrecht.nl Summary Current Opinion in HIV and AIDS 2008, 3:627– Further studies are necessary to unravel the mechanism, the clinical relevance and potential effect of transmission of these cleavage site changes. Keywords Gag cleavage sites, protease inhibitor therapy, resistance Curr Opin HIV AIDS 3:627–632 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins 1746-630X in which all

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Nov 1, 2008

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