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CASE REPORT Novel Clonal t(2;4) (q23;p14) Secondary Cytogenetic Abnormality in a Primary Myxoid Liposarcoma Amber Kiyani, DDS,* Nyla A. Heerema, PhD,w Joel L. Mayerson, MD,z Thomas J. Scharschmidt, MD,z and Obiajulu H. Iwenofu, MDw myxoid end of the spectrum (myxoid liposarcoma) and Abstract: Myxoid liposarcomas are malignant lipomatous tu- the high-grade round cell type (round cell liposarcoma) mors with a predilection for young adults. They are charac- with both harboring the same defining t(12;16)(q13;p11.2) terized by the presence of reciprocal translocation between the 2 or t(12;22)(q13;q12) cytogenetic abnormality. Myxoid/ CHOP (DDIT3) gene on chromosome 12 and the FUS gene on round cell liposarcomas have a tendency to recur locally chromosome 16, t(12;16)(q13;p11.2) in >95% of cases, or less 1,3 and have a metastatic rate of about 30%. The prog- commonly, a translocation between the DDIT3 and EWSR1 nosis is dependent on the clinical stage and histologic genes, t(12;22)(q13;q12). Secondary aberrations involving tris- grade, as defined by the percentage of round cell omy 8 and chromosomes 1 and 16 have been reported. Herein, component within the tumor. Approximately, 95% of we report for the first time a novel secondary clonal trans- myxoid/round cell liposarcomas consistently show a location, t(2;4) (q23;p14)
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Aug 1, 2015
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