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Nottingham-defined Mitotic Score: Comparison With Visual and Image Cytometric Phosphohistone H3 Labeling Indices and Correlation With Oncotype DX Recurrence Score

Nottingham-defined Mitotic Score: Comparison With Visual and Image Cytometric Phosphohistone H3... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9lBjFbu9i0DAnSw4JagSjiU on 10/28/2020 RESEARCH ARTICLE Nottingham-defined Mitotic Score: Comparison With Visual and Image Cytometric Phosphohistone H3 Labeling Indices and Correlation With Oncotype DX Recurrence Score Blazej Zbytek, MD, PhD,*w Cynthia Cohen, MD,w Jason Wang, MD,w Andrew Page, MD,z Daron J. Williams, MD,y and Amy L. Adams, MDw methods studied may be useful in assessing tumor grade, pro- Abstract: Prognosis of breast cancer patients has been de- liferation, and prognosis. termined traditionally by lymph node status, tumor size, and Key Words: breast, mitoses, phosphohistone H3, Oncotype DX histologic grade. In recent years the Oncotype DX recurrence RS score (RS) assay has emerged as an expensive adjunct prognostic tool. Markers of proliferation play a large role in determination (Appl Immunohistochem Mol Morphol 2013;21:48–53) of RS, and we have shown previously that immunohisto- chemical expression of proliferation markers Ki-67 and phos- phohistone H3 (PPH3) correlates with RS. Our current goal is n 2010, an estimated 207,090 new cases of invasive comparison of the hematoxylin and eosin (H&E) mitotic score, Ibreast cancer were expected to be diagnosed in women defined by the Nottingham grading system, with anti-PPH3 in the United States, along with 54,010 new cases of mitotic figure http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Nottingham-defined Mitotic Score: Comparison With Visual and Image Cytometric Phosphohistone H3 Labeling Indices and Correlation With Oncotype DX Recurrence Score

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Publisher
Wolters Kluwer Health
Copyright
© 2013 Lippincott Williams & Wilkins, Inc.
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3182427cda
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9lBjFbu9i0DAnSw4JagSjiU on 10/28/2020 RESEARCH ARTICLE Nottingham-defined Mitotic Score: Comparison With Visual and Image Cytometric Phosphohistone H3 Labeling Indices and Correlation With Oncotype DX Recurrence Score Blazej Zbytek, MD, PhD,*w Cynthia Cohen, MD,w Jason Wang, MD,w Andrew Page, MD,z Daron J. Williams, MD,y and Amy L. Adams, MDw methods studied may be useful in assessing tumor grade, pro- Abstract: Prognosis of breast cancer patients has been de- liferation, and prognosis. termined traditionally by lymph node status, tumor size, and Key Words: breast, mitoses, phosphohistone H3, Oncotype DX histologic grade. In recent years the Oncotype DX recurrence RS score (RS) assay has emerged as an expensive adjunct prognostic tool. Markers of proliferation play a large role in determination (Appl Immunohistochem Mol Morphol 2013;21:48–53) of RS, and we have shown previously that immunohisto- chemical expression of proliferation markers Ki-67 and phos- phohistone H3 (PPH3) correlates with RS. Our current goal is n 2010, an estimated 207,090 new cases of invasive comparison of the hematoxylin and eosin (H&E) mitotic score, Ibreast cancer were expected to be diagnosed in women defined by the Nottingham grading system, with anti-PPH3 in the United States, along with 54,010 new cases of mitotic figure

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2013

Keywords: breast,mitoses,phosphohistone H3,Oncotype DX RS

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