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New Territory Surgical Salvage for Stereotactic Body Radiation Therapy Failures in Lung Cancer

New Territory Surgical Salvage for Stereotactic Body Radiation Therapy Failures in Lung Cancer EDITORIAL New Territory Surgical Salvage for Stereotactic Body Radiation Therapy Failures in Lung Cancer Jeffrey Bradley, MD n this issue of the Journal of Thoracic Oncology, Neri et al. present the first report of Ipatients who underwent surgical salvage after stereotactic body radiation therapy (SBRT) for primary or metastatic lung cancer. This report is of value because it shows that a surgical salvage strategy is feasible for operable patients, and, at least in these seven patients, the surgery was accomplished without difficulty. Local recurrence rates after SBRT for stage I lung cancers range between 5 and 15%. RTOG 0236 was a prospective multiinstitutional trial that delivered 54 Gy in three fractions over 7 to 10 days to medically inoperable patients and demonstrated a 3-year local control rate of 94%. Similar to the patients on this Radiation Therapy Oncology Group (RTOG) study, most patients receiving SBRT to the malignant lesions in the lung today are not eligible for surgery because of baseline pulmonary function, underlying cardiac disease, marginal performance status, or a combination of these factors. Therefore, salvage surgery has not often been a consideration for these patients. As the data supporting SBRT in lung cancer and limited metastatic disease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

New Territory Surgical Salvage for Stereotactic Body Radiation Therapy Failures in Lung Cancer

Bradley, Jeffrey
Journal of Thoracic Oncology , Volume 5 (12) – Dec 1, 2010
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e318200dea6
pmid
21102255
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL New Territory Surgical Salvage for Stereotactic Body Radiation Therapy Failures in Lung Cancer Jeffrey Bradley, MD n this issue of the Journal of Thoracic Oncology, Neri et al. present the first report of Ipatients who underwent surgical salvage after stereotactic body radiation therapy (SBRT) for primary or metastatic lung cancer. This report is of value because it shows that a surgical salvage strategy is feasible for operable patients, and, at least in these seven patients, the surgery was accomplished without difficulty. Local recurrence rates after SBRT for stage I lung cancers range between 5 and 15%. RTOG 0236 was a prospective multiinstitutional trial that delivered 54 Gy in three fractions over 7 to 10 days to medically inoperable patients and demonstrated a 3-year local control rate of 94%. Similar to the patients on this Radiation Therapy Oncology Group (RTOG) study, most patients receiving SBRT to the malignant lesions in the lung today are not eligible for surgery because of baseline pulmonary function, underlying cardiac disease, marginal performance status, or a combination of these factors. Therefore, salvage surgery has not often been a consideration for these patients. As the data supporting SBRT in lung cancer and limited metastatic disease

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Dec 1, 2010

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