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New Perspectives of the Pathophysiology and Management in Heart Failure

New Perspectives of the Pathophysiology and Management in Heart Failure HIGHLIGHTS FROM THE 2015 SOUTHERN REGIONAL MEETING New Perspectives of the Pathophysiology and Management in Heart Failure Daniel Villarreal, MD eart failure constitutes a significant source of morbidity and its treatment continues to be challenging and is far from H mortality worldwide, and with its ever-growing incidence optimal. and prevalence, the burden on the health care system is stag- In this state of the art symposium, Dr. Patrice Delafon- taine from the University of Missouri-Columbia discusses novel gering. Approximately 5.6 million Americans suffer from heart failure, and more than 650,000 new cases are diagnosed each and timely perspectives on the pathophysiologic mechanisms year in the United States. Its incidence approaches 10 per 1,000 and treatment of cachexia in heart failure. His pioneer and in their older than 65 years and accounts for 1 million hospital- insightful research in these areas will clearly advance both the izations and 3 million office visits annually. Moreover, patients understanding and thee comprehensive management of this diagnosed with heart failure experience sudden cardiac death at highly morbid and prevalent disease. 6 to 8 times the rate of the general population. Globally, the demographics are similar, with an estimated 5.7 million diag- REFERENCES nosed with heart failure each year. The average prevalence of 1. Yancey CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline heart failure worldwide is 2% to 2.5% and increases to more for the management of heart failure. J Am Coll Cardiol 2013;62: than 10% in octogenarians. The direct and indirect costs of this e147–239. epidemic in the United States in 2012 approximated $30 billion, 2. Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke and it is anticipated that these costs will continue to rise over statistics 2009 update. A report from the American heart Association the next decade. Committee and Stroke Statistics Subcommittee. Circulation 2009;119: Although recent progress has been made in the manage- 480–6. ment of heart failure symptoms and its quality of life, the 3. World Health Organization. The Global Burden of Disease-2004 absolute mortality of approximately 50% at 5 years after Update. Geneva, Switzerland: WHO 2008; Press:27–38. diagnosis remains virtually unchanged over the last half century. This is related, in part, to the complex and incom- 4. Sanderson JE, Tse TF. Heart failure: a global disease requiring a global pletely defined pathophysiology of the disease. Consequently, response. Heart 2003;89:585–6. From the Division of Cardiology, SUNY Upstate Medical University, Syracuse, New York. The author has no financial or other conflicts of interest to disclose. Presented as part of the Southern Regional Meeting, the Southern Soci- ety for Clinical Investigation’s Presidential Symposium, February 27, 2015, New Orleans, LA. Correspondence: Daniel Villarreal, MD, Division of Cardiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210 (E-mail: villarrd@upstate.edu). The American Journal of the Medical Sciences Volume 0, Number 0, Month 2015 Copyright  2015 by the Southern Society for Clinical Investigation. Unauthorized reproduction of this article is prohibited. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of the Medical Sciences Wolters Kluwer Health

New Perspectives of the Pathophysiology and Management in Heart Failure

Villarreal, Daniel
American Journal of the Medical Sciences , Volume Publish Ahead of Print – Sep 1, 2015
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References (3)

Copyright
Copyright © 2015 by the Southern Society for Clinical Investigation.
ISSN
0002-9629
eISSN
1538-2990
DOI
10.1097/MAJ.0000000000000582
pmid
26418378
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Abstract

HIGHLIGHTS FROM THE 2015 SOUTHERN REGIONAL MEETING New Perspectives of the Pathophysiology and Management in Heart Failure Daniel Villarreal, MD eart failure constitutes a significant source of morbidity and its treatment continues to be challenging and is far from H mortality worldwide, and with its ever-growing incidence optimal. and prevalence, the burden on the health care system is stag- In this state of the art symposium, Dr. Patrice Delafon- taine from the University of Missouri-Columbia discusses novel gering. Approximately 5.6 million Americans suffer from heart failure, and more than 650,000 new cases are diagnosed each and timely perspectives on the pathophysiologic mechanisms year in the United States. Its incidence approaches 10 per 1,000 and treatment of cachexia in heart failure. His pioneer and in their older than 65 years and accounts for 1 million hospital- insightful research in these areas will clearly advance both the izations and 3 million office visits annually. Moreover, patients understanding and thee comprehensive management of this diagnosed with heart failure experience sudden cardiac death at highly morbid and prevalent disease. 6 to 8 times the rate of the general population. Globally, the demographics are similar, with an estimated 5.7 million diag- REFERENCES nosed with heart failure each year. The average prevalence of 1. Yancey CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline heart failure worldwide is 2% to 2.5% and increases to more for the management of heart failure. J Am Coll Cardiol 2013;62: than 10% in octogenarians. The direct and indirect costs of this e147–239. epidemic in the United States in 2012 approximated $30 billion, 2. Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke and it is anticipated that these costs will continue to rise over statistics 2009 update. A report from the American heart Association the next decade. Committee and Stroke Statistics Subcommittee. Circulation 2009;119: Although recent progress has been made in the manage- 480–6. ment of heart failure symptoms and its quality of life, the 3. World Health Organization. The Global Burden of Disease-2004 absolute mortality of approximately 50% at 5 years after Update. Geneva, Switzerland: WHO 2008; Press:27–38. diagnosis remains virtually unchanged over the last half century. This is related, in part, to the complex and incom- 4. Sanderson JE, Tse TF. Heart failure: a global disease requiring a global pletely defined pathophysiology of the disease. Consequently, response. Heart 2003;89:585–6. From the Division of Cardiology, SUNY Upstate Medical University, Syracuse, New York. The author has no financial or other conflicts of interest to disclose. Presented as part of the Southern Regional Meeting, the Southern Soci- ety for Clinical Investigation’s Presidential Symposium, February 27, 2015, New Orleans, LA. Correspondence: Daniel Villarreal, MD, Division of Cardiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210 (E-mail: villarrd@upstate.edu). The American Journal of the Medical Sciences Volume 0, Number 0, Month 2015 Copyright  2015 by the Southern Society for Clinical Investigation. Unauthorized reproduction of this article is prohibited.

Journal

American Journal of the Medical Sciences – Wolters Kluwer Health

Published: Sep 1, 2015

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