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New developments in the understanding of immunology in silicosis Franc ¸ois Huaux Purpose of review Introduction There is compelling evidence that the immune responses Contrary to common opinion, interstitial pulmonary fibro- induced by crystalline silica particles are implicated in the sis resulting from workplace exposure to crystalline silica development of silicosis. This article reviews recent particles (silicosis) is not a disease of the past, in particular observations which further delineate how innate and in developing countries the situation appears very preva- adaptive immunity are involved in this lung disease. lent [1]. Several lines of evidence support the view that Recent findings the pathogenesis of silicosis involves uncontrolled First, silica particles are recognized to have pathogen- immune processes. Indeed, the fundamental concept, associated molecular patterns by the innate immune usually put forward to explain the pathogenesis of this system. The MARCO receptor expressed on the surface of disease, is relatively simple: a chronic inflammatory macrophages appears crucial for the recognition and the status (referred to as alveolitis) in which the immune uptake of silica as well as the activation of these immune cells are activated and release toxic mediators, damages cells in silicosis. Additional data support a major role of
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Apr 1, 2007
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