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Neuronatin Expression and Its Clinicopathological Significance in Pulmonary Non-small Cell Carcinoma

Neuronatin Expression and Its Clinicopathological Significance in Pulmonary Non-small Cell Carcinoma ORIGINAL ARTICLE Neuronatin Expression and Its Clinicopathological Significance in Pulmonary Non-small Cell Carcinoma Teruhito Uchihara, MD,*† Chigusa Okubo, MS,† Ryota Tanaka, MD,‡ Yuko Minami, MD,§ Yukinori Inadome, MD,† Tatsuo Iijima, MD,† Yukio Morishita, MD,† Jiro Fujita, MD,* and Masayuki Noguchi, MD† euronatin is a protein that is specifically expressed in the Introduction: Neuronatin is a protein that is specifically expressed Nnervous system in the course of embryonal brain devel- in the nervous system in the course of embryonal brain development, opment in mammals. Neuronatin was initially discovered in and its expression is limited to the pituitary gland in normal human rats during a search for genes considered to be important for adults. Neuronatin expression has been reported in some types of development of the central nervous system. In the mamma- tumor. The purpose of this study was to clarify the significance of lian fetus, neuronatin seems to contribute to the development neuronatin expression in pulmonary non-small cell carcinoma. and maturation of the hindbrain and pituitary gland. During Methods: We determined the frequency of neuronatin expression in later embryogenesis, the neuronatin gene is strongly ex- surgically resected samples from non-small cell lung carcinoma (51 pressed in the major part of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Neuronatin Expression and Its Clinicopathological Significance in Pulmonary Non-small Cell Carcinoma

Noguchi, Masayuki
Journal of Thoracic Oncology , Volume 2 (9) – Sep 1, 2007
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References (22)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e318145af5e
pmid
17805055
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Neuronatin Expression and Its Clinicopathological Significance in Pulmonary Non-small Cell Carcinoma Teruhito Uchihara, MD,*† Chigusa Okubo, MS,† Ryota Tanaka, MD,‡ Yuko Minami, MD,§ Yukinori Inadome, MD,† Tatsuo Iijima, MD,† Yukio Morishita, MD,† Jiro Fujita, MD,* and Masayuki Noguchi, MD† euronatin is a protein that is specifically expressed in the Introduction: Neuronatin is a protein that is specifically expressed Nnervous system in the course of embryonal brain devel- in the nervous system in the course of embryonal brain development, opment in mammals. Neuronatin was initially discovered in and its expression is limited to the pituitary gland in normal human rats during a search for genes considered to be important for adults. Neuronatin expression has been reported in some types of development of the central nervous system. In the mamma- tumor. The purpose of this study was to clarify the significance of lian fetus, neuronatin seems to contribute to the development neuronatin expression in pulmonary non-small cell carcinoma. and maturation of the hindbrain and pituitary gland. During Methods: We determined the frequency of neuronatin expression in later embryogenesis, the neuronatin gene is strongly ex- surgically resected samples from non-small cell lung carcinoma (51 pressed in the major part of

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Sep 1, 2007

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