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Neointimal Cracks (Plaque Rupture?) and Thrombosis in Wrapped Arteries Without Flow

Neointimal Cracks (Plaque Rupture?) and Thrombosis in Wrapped Arteries Without Flow Letter to the Editor Neointimal Cracks (Plaque Rupture?) and Thrombosis in Wrapped Arteries Without Flow Erling Falk, Stephen M. Schwartz, Zorina S. Galis, Michael E. Rosenfeld he Editor’s pick for the June 2006 issue of Arterio- leading to gradual thrombotic occlusion of the cuffed seg- sclerosis, Thrombosis, and Vascular Biology was the ment within 7 days (subacute thrombosis). The new observa- 1 1 article by Sasaki et al entitled “A Simple Method of tion just reported by Sasaki et al is that the same happens Plaque Rupture Induction in Apolipoprotein E–Deficient when the nonconstrictive cuff is placed around a ligated CCA Mice.” The key term in this title is “plaque rupture.” The that already has a neointima in apoE-deficient mice. Under article was accompanied by a supportive editorial by Jack- this condition the neointima becomes disrupted (called son. We would like to suggest that the enthusiasm for this “plaque rupture”), and the stagnant blood within the cuff experiment as a model for plaque rupture needs to be clots. In both Sasaki models, the nourishment of the arterial moderated by a better understanding of the model itself and wall was first compromised by stopping the flow of blood in of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

Neointimal Cracks (Plaque Rupture?) and Thrombosis in Wrapped Arteries Without Flow

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ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/01.ATV.0000249644.86759.81
pmid
17185623

Abstract

Letter to the Editor Neointimal Cracks (Plaque Rupture?) and Thrombosis in Wrapped Arteries Without Flow Erling Falk, Stephen M. Schwartz, Zorina S. Galis, Michael E. Rosenfeld he Editor’s pick for the June 2006 issue of Arterio- leading to gradual thrombotic occlusion of the cuffed seg- sclerosis, Thrombosis, and Vascular Biology was the ment within 7 days (subacute thrombosis). The new observa- 1 1 article by Sasaki et al entitled “A Simple Method of tion just reported by Sasaki et al is that the same happens Plaque Rupture Induction in Apolipoprotein E–Deficient when the nonconstrictive cuff is placed around a ligated CCA Mice.” The key term in this title is “plaque rupture.” The that already has a neointima in apoE-deficient mice. Under article was accompanied by a supportive editorial by Jack- this condition the neointima becomes disrupted (called son. We would like to suggest that the enthusiasm for this “plaque rupture”), and the stagnant blood within the cuff experiment as a model for plaque rupture needs to be clots. In both Sasaki models, the nourishment of the arterial moderated by a better understanding of the model itself and wall was first compromised by stopping the flow of blood in of

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Jan 1, 2007

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