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Myocardial Function in Secondary Mitral Regurgitation

Myocardial Function in Secondary Mitral Regurgitation Circulation: Cardiovascular Imaging EDITORIAL Myocardial Function in Secondary Mitral Regurgitation A Challenging Relationship Daniel Lavall , MD; Stephan Stöbe , MD econdary mitral regurgitation (MR) is a common assessment of LVEF is that it comprises the loading con- complication of chronic heart failure with reduced ditions and allows determination of LV contractility. The Sleft ventricular (LV) ejection fraction (EF). It results area under the pressure-volume curve represents myo- from eccentric LV remodeling (increasing tethering cardial work, a measure of myocardial oxygen demand, forces), LV dysfunction (reduced closing forces), mitral which is critical in heart failure. However, approaches annulus dilatation, or a combination of these mecha- to calculate pressure-volume curves are complex and nisms. Any severity of secondary MR impairs the prog- time consuming which limits their use in clinical practice. nosis of patients with heart failure, even mild secondary Pressure-strain curves, derived from speckle-tracking MR. Despite this well-established symptomatic and echocardiography and noninvasive blood pressure mea- prognostic impact of secondary MR, open questions surement, serve as a marker of myocardial work, which 8–11 remain with regard to surgical and interventional mitral correlates closely with myocardial metabolic demand. valve repair, especially since the COAPT (Cardiovascular Since the pressure-strain curves can http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Cardiovascular Imaging Wolters Kluwer Health

Myocardial Function in Secondary Mitral Regurgitation

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Publisher
Wolters Kluwer Health
Copyright
© 2021 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/circimaging.121.013350
Publisher site
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Abstract

Circulation: Cardiovascular Imaging EDITORIAL Myocardial Function in Secondary Mitral Regurgitation A Challenging Relationship Daniel Lavall , MD; Stephan Stöbe , MD econdary mitral regurgitation (MR) is a common assessment of LVEF is that it comprises the loading con- complication of chronic heart failure with reduced ditions and allows determination of LV contractility. The Sleft ventricular (LV) ejection fraction (EF). It results area under the pressure-volume curve represents myo- from eccentric LV remodeling (increasing tethering cardial work, a measure of myocardial oxygen demand, forces), LV dysfunction (reduced closing forces), mitral which is critical in heart failure. However, approaches annulus dilatation, or a combination of these mecha- to calculate pressure-volume curves are complex and nisms. Any severity of secondary MR impairs the prog- time consuming which limits their use in clinical practice. nosis of patients with heart failure, even mild secondary Pressure-strain curves, derived from speckle-tracking MR. Despite this well-established symptomatic and echocardiography and noninvasive blood pressure mea- prognostic impact of secondary MR, open questions surement, serve as a marker of myocardial work, which 8–11 remain with regard to surgical and interventional mitral correlates closely with myocardial metabolic demand. valve repair, especially since the COAPT (Cardiovascular Since the pressure-strain curves can

Journal

Circulation Cardiovascular Imaging – Wolters Kluwer Health

Published: Sep 15, 2021

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