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Multiple action agents and the eye: do they really stabilize mast cells? a a,b a Alessandro Lambiase , Alessandra Micera and Stefano Bonini CIR Laboratory of Ophthalmology, University Campus Purpose of review Bio-Medico and IRCCS-G.B. Bietti Eye Foundation, Multiple action drugs, such as azelastine, epinastine, ketotifen and olopatadine, have Rome, Italy recently been suggested to combine antihistaminic effect, mast cell stabilization Correspondence to Stefano Bonini, MD, Full Professor, and anti-inflammatory action. This pharmaceutical class is, therefore, rapidly becoming Department of Ophthalmology, University Campus Bio- Medico, Via Alvaro del Portillo 21, Rome 00128, Italy the first choice for prevention and treatment for allergic conjunctivitis. Tel: +39 06225419185; fax: +39 0622541456; Recent findings e-mail: s.bonini@unicampus.it Increasing in-vitro studies have been performed to investigate the mast-cell-stabilizing Current Opinion in Allergy and Clinical effect of multiple action drugs. Most of the study results agree that these drugs are able Immunology 2009, 9:454–465 to inhibit histamine and several neoformed mediators, including cytokines and arachidonic acid-derived products, from mast cells. However, the mechanisms of action have not yet fully been elucidated. Most of the results from clinical trials as well as the in-vivo experimental studies, including the conjunctival provocation model, support the evidence of a
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Oct 1, 2009
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