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ORIGINAL ARTICLE Multiparametric Magnetic Resonance Imaging Characterization of Prostate Lesions in the Active Surveillance Population: Incremental Value of Magnetic Resonance Imaging for Prediction of Disease Reclassification David Bonekamp, MD, PhD,* Susanne Bonekamp, DVM, PhD,* Jeffrey K. Mullins, MD,† Jonathan I. Epstein, MD,‡ H. Ballentine Carter, MD,† and Katarzyna J. Macura, MD, PhD* upstaging with immediate repeat biopsy. Repeat biopsies them- Objective: This study aimed to characterize prostate lesions by multi- selves undersample the prostate such that even multiple negative parametric magnetic resonance imaging (MRI) in active surveillance or low-grade biopsies carry a risk of missing aggressive PCa, (AS) and examine the incremental predictive value of MRI in comparison 7 and deaths occur after follow-up. Active surveillance enrollment with clinical parameters for disease reclassification. criteria without the use of magnetic resonance imaging (MRI) Methods: Blinded imaging review of 3-Tendorectal mMRI from 50 con- have been found to be associated with Gleason score upgrading secutive men was performed. Multiparametric MRI biomarkers and mor- 8 and T3 (not organ-confined disease) disease at surgery. In several 4 9 phological parameters and the predictive value of a suspicious MR lesion series, T3 disease was found in 35% /58% of cases at radical of 10
Journal of Computer Assisted Tomography – Wolters Kluwer Health
Published: Nov 1, 2013
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