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Multiparametric Magnetic Resonance Imaging Characterization of Prostate Lesions in the Active Surveillance Population Incremental Value of Magnetic Resonance Imaging for Prediction of Disease Reclassification

Multiparametric Magnetic Resonance Imaging Characterization of Prostate Lesions in the Active... ORIGINAL ARTICLE Multiparametric Magnetic Resonance Imaging Characterization of Prostate Lesions in the Active Surveillance Population: Incremental Value of Magnetic Resonance Imaging for Prediction of Disease Reclassification David Bonekamp, MD, PhD,* Susanne Bonekamp, DVM, PhD,* Jeffrey K. Mullins, MD,† Jonathan I. Epstein, MD,‡ H. Ballentine Carter, MD,† and Katarzyna J. Macura, MD, PhD* upstaging with immediate repeat biopsy. Repeat biopsies them- Objective: This study aimed to characterize prostate lesions by multi- selves undersample the prostate such that even multiple negative parametric magnetic resonance imaging (MRI) in active surveillance or low-grade biopsies carry a risk of missing aggressive PCa, (AS) and examine the incremental predictive value of MRI in comparison 7 and deaths occur after follow-up. Active surveillance enrollment with clinical parameters for disease reclassification. criteria without the use of magnetic resonance imaging (MRI) Methods: Blinded imaging review of 3-Tendorectal mMRI from 50 con- have been found to be associated with Gleason score upgrading secutive men was performed. Multiparametric MRI biomarkers and mor- 8 and T3 (not organ-confined disease) disease at surgery. In several 4 9 phological parameters and the predictive value of a suspicious MR lesion series, T3 disease was found in 35% /58% of cases at radical of 10 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Computer Assisted Tomography Wolters Kluwer Health

Multiparametric Magnetic Resonance Imaging Characterization of Prostate Lesions in the Active Surveillance Population Incremental Value of Magnetic Resonance Imaging for Prediction of Disease Reclassification

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
0363-8715
eISSN
1532-3145
DOI
10.1097/RCT.0b013e31829ae20a
pmid
24270118
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Multiparametric Magnetic Resonance Imaging Characterization of Prostate Lesions in the Active Surveillance Population: Incremental Value of Magnetic Resonance Imaging for Prediction of Disease Reclassification David Bonekamp, MD, PhD,* Susanne Bonekamp, DVM, PhD,* Jeffrey K. Mullins, MD,† Jonathan I. Epstein, MD,‡ H. Ballentine Carter, MD,† and Katarzyna J. Macura, MD, PhD* upstaging with immediate repeat biopsy. Repeat biopsies them- Objective: This study aimed to characterize prostate lesions by multi- selves undersample the prostate such that even multiple negative parametric magnetic resonance imaging (MRI) in active surveillance or low-grade biopsies carry a risk of missing aggressive PCa, (AS) and examine the incremental predictive value of MRI in comparison 7 and deaths occur after follow-up. Active surveillance enrollment with clinical parameters for disease reclassification. criteria without the use of magnetic resonance imaging (MRI) Methods: Blinded imaging review of 3-Tendorectal mMRI from 50 con- have been found to be associated with Gleason score upgrading secutive men was performed. Multiparametric MRI biomarkers and mor- 8 and T3 (not organ-confined disease) disease at surgery. In several 4 9 phological parameters and the predictive value of a suspicious MR lesion series, T3 disease was found in 35% /58% of cases at radical of 10

Journal

Journal of Computer Assisted TomographyWolters Kluwer Health

Published: Nov 1, 2013

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