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Molecular Markers in Thyroid Fine-needle Aspiration Biopsy: A Prospective Study

Molecular Markers in Thyroid Fine-needle Aspiration Biopsy: A Prospective Study Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Molecular Markers in Thyroid Fine-needle Aspiration Biopsy A Prospective Study Carmen Franco, MD,* Virginia Martı´nez, MD,* Juan Pablo Allamand, MD,w Francisco Medina, MD,z Andrea Glasinovic, MD,z Miren Osorio, MD,y and Dina Schachter, MDy hyroid nodules are a frequent problem in the general Background: Fine-needle aspiration biopsy (FNAB) is the most Tpopulation. Ultrasonographic (US) examinations accurate study in the preoperative evaluation of patients with reveal that 20% to 35% of the people have nodules. thyroid nodules. However, one of its limitations is the Most of them are benign and may be treated conserva- indeterminate or suspicious sample which accounts for 15% to tively. However, some factors like exposure to radiation, 25% of the cases; both follicular and Hurthle cell neoplasms are male sex, family history, etc., raise the possibility of included in this category. malignancy. On the other hand, most patients with thyroid cancer do not belong to any risk group. Objective: To assess the accuracy of the molecular markers Of all the examinations performed in the evaluation of HBME-1 and galectin-3 in suspicious or indeterminate FNABs patients with thyroid nodules, fine-needle aspiration biopsy comparing the results with the histologic diagnosis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

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Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31818935a9
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Molecular Markers in Thyroid Fine-needle Aspiration Biopsy A Prospective Study Carmen Franco, MD,* Virginia Martı´nez, MD,* Juan Pablo Allamand, MD,w Francisco Medina, MD,z Andrea Glasinovic, MD,z Miren Osorio, MD,y and Dina Schachter, MDy hyroid nodules are a frequent problem in the general Background: Fine-needle aspiration biopsy (FNAB) is the most Tpopulation. Ultrasonographic (US) examinations accurate study in the preoperative evaluation of patients with reveal that 20% to 35% of the people have nodules. thyroid nodules. However, one of its limitations is the Most of them are benign and may be treated conserva- indeterminate or suspicious sample which accounts for 15% to tively. However, some factors like exposure to radiation, 25% of the cases; both follicular and Hurthle cell neoplasms are male sex, family history, etc., raise the possibility of included in this category. malignancy. On the other hand, most patients with thyroid cancer do not belong to any risk group. Objective: To assess the accuracy of the molecular markers Of all the examinations performed in the evaluation of HBME-1 and galectin-3 in suspicious or indeterminate FNABs patients with thyroid nodules, fine-needle aspiration biopsy comparing the results with the histologic diagnosis

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: May 1, 2009

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