Access the full text.
Sign up today, get DeepDyve free for 14 days.
Z. Sahul, R. Mukherjee, James Song, J. Mcateer, Robert Stroud, D. Dione, L. Staib, X. Papademetris, L. Dobrucki, J. Duncan, F. Spinale, A. Sinusas (2011)
Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling: Relationship to Myocardial DysfunctionCirculation: Cardiovascular Imaging, 4
L. Dobrucki, E. Muinck, J. Lindner, A. Sinusas (2010)
Approaches to Multimodality Imaging of AngiogenesisJournal of Nuclear Medicine, 51
S. Chadderdon, J Belcik, L. Bader, M. Kirigiti, D. Peters, P. Kievit, K. Grove, J. Lindner, Kevin Ve (2014)
Proinflammatory Endothelial Activation Detected by Molecular Imaging in Obese Nonhuman Primates Coincides With Onset of Insulin Resistance and Progressively Increases With Duration of Insulin ResistanceCirculation, 129
S. Chitneni, G. Palmer, M. Zalutsky, M. Dewhirst (2011)
Molecular Imaging of HypoxiaThe Journal of Nuclear Medicine, 52
I. Chen, Joseph Wu (2013)
Molecular imaging: the key to advancing cardiac stem cell therapy.Trends in cardiovascular medicine, 23 6
Jingxiong Wang, A. Najjar, Sui Zhang, B. Rabinovich, J. Willerson, J. Gelovani, E. Yeh (2012)
Molecular Imaging of Mesenchymal Stem Cell: Mechanistic Insight Into Cardiac Repair After Experimental Myocardial InfarctionCirculation: Cardiovascular Imaging, 5
M. Gyöngyösi, R. Hemetsberger, S. Wolbank, C. Kaun, A. Pósa, T. Márián, L. Balkay, M. Emri, L. Galuska, P. Mikecz, Z. Petrási, Silvia Charwat, Hani Hemetsberger, J. Blanco, G. Maurer (2010)
Imaging the migration of therapeutically delivered cardiac stem cells.JACC. Cardiovascular imaging, 3 7
Nynke Jager, J. Westra, R. Golestani, G. Dam, P. Low, R. Tio, R. Slart, H. Boersma, M. Bijl, C. Zeebregts (2014)
Folate Receptor-β Imaging Using 99mTc-Folate to Explore Distribution of Polarized Macrophage Populations in Human Atherosclerotic PlaqueThe Journal of Nuclear Medicine, 55
T. Quillard, K. Croce, F. Jaffer, R. Weissleder, P. Libby (2011)
Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivoThrombosis and Haemostasis, 105
T. Quillard, P. Libby (2012)
Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development.Circulation research, 111 2
K. Ransohoff, Joseph Wu (2010)
Advances in cardiovascular molecular imaging for tracking stem cell therapyThrombosis and Haemostasis, 104
H. Naci, A. Carter, Elias Mossialos (2015)
Why the drug development pipeline is not delivering better medicinesBMJ : British Medical Journal, 351
Jun Tang, M. Lobatto, J. Read, A. Mieszawska, Z. Fayad, W. Mulder (2011)
Nanomedical Theranostics in Cardiovascular DiseaseCurrent Cardiovascular Imaging Reports, 5
R. Macarron, M. Banks, D. Bojanic, David Burns, D. Cirovic, T. Garyantes, D. Green, R. Hertzberg, W. Janzen, J. Paslay, U. Schopfer, G. Sittampalam (2011)
Impact of high-throughput screening in biomedical researchNature Reviews Drug Discovery, 10
Yasuyoshi Watanabe (2007)
[Molecular imaging for drug development].Brain and nerve = Shinkei kenkyu no shinpo, 59 3
Jonathan Lindner, M. Coggins, Sanjiv Kaul, Alexander Klibanov, G. Brandenburger, Klaus Ley (2000)
Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes.Circulation, 101 6
Soo-Min Shon, Yongdoo Choi, Jeongyeon Kim, Dong Lee, Jin‐Yong Park, D. Schellingerhout, Dong-Eog Kim (2013)
Photodynamic Therapy Using a Protease-Mediated Theranostic Agent Reduces Cathepsin-B Activity in Mouse Atheromata In VivoArteriosclerosis, Thrombosis, and Vascular Biology, 33
P. Winter, S. Caruthers, Huiying Zhang, T. Williams, S. Wickline, G. Lanza (2008)
Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis.JACC. Cardiovascular imaging, 1 5
M. Bonios, J. Terrovitis, Connie Chang, J. Engles, T. Higuchi, R. Lautamäki, Jianhua Yu, J. Fox, M. Pomper, R. Wahl, B. Tsui, B. O’Rourke, F. Bengel, E. Marbán, M. Abraham (2011)
Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cellsJournal of Nuclear Cardiology, 18
Asher Mullard (2017)
2016 FDA drug approvalsNature Reviews Drug Discovery, 16
L. Cunha, K. Szigeti, D. Máthé, L. Metello (2014)
The role of molecular imaging in modern drug development.Drug discovery today, 19 7
Jp Hughes, S. Rees, SB Kalindjian, KL Philpott (2011)
Principles of early drug discoveryBritish Journal of Pharmacology, 162
F. Swirski, M. Nahrendorf (2013)
Imaging macrophage development and fate in atherosclerosis and myocardial infarctionImmunology and Cell Biology, 91
D. Buxton (2012)
Molecular Imaging of Aortic AneurysmsCirculation: Cardiovascular Imaging, 5
(2013)
Noninvasive ultrasound molecular imaging of the effect 11 Lindner and Link Molecular Imaging in Drug Development of statins on endothelial inflammatory phenotype in early atherosclerosis
S. Tsimikas, W. Palinski, S. Halpern, D. Yeung, L. Curtiss, J. Witztum (1999)
Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivoJournal of Nuclear Cardiology, 6
J. Garner, B. Gaskill, Elin Weber, Jamie Ahloy-Dallaire, K. Pritchett-Corning (2017)
Introducing Therioepistemology: the study of how knowledge is gained from animal researchLab Animal, 46
J. Stendahl, A. Sinusas (2015)
Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and FeaturesThe Journal of Nuclear Medicine, 56
M. Nahrendorf, F. Jaffer, K. Kelly, D. Sosnovik, E. Aikawa, P. Libby, R. Weissleder (2006)
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in AtherosclerosisCirculation, 114
I. Carrió, M. Cowie, J. Yamazaki, J. Udelson, P. Camici (2010)
Cardiac sympathetic imaging with mIBG in heart failure.JACC. Cardiovascular imaging, 3 1
G. Gebhart, L. Lamberts, Z. Wimana, C. Garcia, Patrick Emonts, L. Ameye, S. Stroobants, M. Huizing, P. Aftimos, J. Tol, W. Oyen, D. Vugts, O. Hoekstra, C. Schröder, Catharina van, Oordt, T. Guiot, A. Brouwers, A. Awada, E. Vries, P. Flamen (2016)
Molecular imaging as a tool to investigate heterogeneity of advanced HER2-positive breast cancer and to predict patient outcome under trastuzumab emtansine (T-DM1): the ZEPHIR trial.Annals of oncology : official journal of the European Society for Medical Oncology, 27 4
B. Kietselaer, C. Reutelingsperger, G. Heidendal, M. Daemen, W. Mess, L. Hofstra, J. Narula (2004)
Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis.The New England journal of medicine, 350 14
N. Tahara, J. Mukherjee, H. Haas, A. Petrov, A. Tawakol, Nezam Haider, Atsuko Tahara, C. Constantinescu, Jun Zhou, H. Boersma, T. Imaizumi, M. Nakano, A. Finn, Z. Fayad, R. Virmani, V. Fuster, L. Boscá, J. Narula (2014)
2-deoxy-2-[18F]fluoro-d-mannose positron emission tomography imaging in atherosclerosisNature Medicine, 20
R. Blankstein, M. Osborne, M. Naya, A. Waller, C. Kim, V. Murthy, P. Kazemian, R. Kwong, M. Tokuda, H. Skali, R. Padera, J. Hainer, W. Stevenson, S. Dorbala, M. Carli (2012)
Cardiac positron emission tomography enhances prognostic assessments of patients with suspected cardiac sarcoidosis.Journal of the American College of Cardiology, 63 4
Carolyn Behm, Beat Kaufmann, Chad Carr, Miles Lankford, John Sanders, C. Rose, S. Kaul, Jonathan Lindner (2008)
Molecular Imaging of Endothelial Vascular Cell Adhesion Molecule-1 Expression and Inflammatory Cell Recruitment During Vasculogenesis and Ischemia-Mediated ArteriogenesisCirculation, 117
Jae Ryu, Brian Davidson, Aris Xie, Y. Qi, Dao-gang Zha, J. Belcik, Evan Caplan, J. Woda, Catherine Hedrick, Richard Hanna, N. Lehman, Yan Zhao, A. Ting, Jonathan Lindner (2013)
Molecular Imaging of the Paracrine Proangiogenic Effects of Progenitor Cell Therapy in Limb IschemiaCirculation, 127
H. Jørstad, Ersen Colkesen, S. Boekholdt, J. Tijssen, N. Wareham, K. Khaw, R. Peters, H. Jørstad (2015)
Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular riskHeart, 102
M. Nahrendorf, E. Keliher, Peter Panizzi, Hanwen Zhang, S. Hembrador, Jose-Luiz Figueiredo, E. Aikawa, K. Kelly, P. Libby, R. Weissleder (2009)
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.JACC. Cardiovascular imaging, 2 10
J. Link, J. Caldwell (2008)
Diagnostic and prognostic imaging of the cardiac sympathetic nervous systemNature Clinical Practice Cardiovascular Medicine, 5 Suppl 2
S. Paul, D. Mytelka, C. Dunwiddie, Charles Persinger, B. Munos, S. Lindborg, A. Schacht (2010)
How to improve R&D productivity: the pharmaceutical industry's grand challengeNature Reviews Drug Discovery, 9
A. Sinusas, F. Bengel, M. Nahrendorf, F. Epstein, Joseph Wu, F. Villanueva, Z. Fayad, R. Gropler (2008)
Advances in Cardiovascular Imaging Multimodality Cardiovascular Molecular Imaging, Part I
I. Laitinen, A. Saraste, E. Weidl, T. Poethko, A. Weber, S. Nekolla, P. Leppänen, S. Ylä-Herttuala, G. Hölzlwimmer, A. Walch, I. Esposito, H. Wester, J. Knuuti, M. Schwaiger (2009)
Evaluation of &agr;v&bgr;3 Integrin-Targeted Positron Emission Tomography Tracer 18F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic MiceCirculation: Cardiovascular Imaging, 2
H. Kenis, H. Zandbergen, L. Hofstra, A. Petrov, E. Dumont, Francis Blankenberg, Nezam Haider, N. Bitsch, M. Gijbels, J. Verjans, N. Narula, J. Narula, C. Reutelingsperger (2010)
Annexin A5 Uptake in Ischemic Myocardium: Demonstration of Reversible Phosphatidylserine Externalization and Feasibility of Radionuclide ImagingJournal of Nuclear Medicine, 51
P. Winter, S. Caruthers, J. Allen, K. Cai, T. Williams, G. Lanza, S. Wickline (2010)
Molecular imaging of angiogenic therapy in peripheral vascular disease with ανβ3‐integrin‐targeted nanoparticlesMagnetic Resonance in Medicine, 64
R. Choudhury, E. Fisher (2009)
Molecular imaging in atherosclerosis, thrombosis, and vascular inflammation.Arteriosclerosis, thrombosis, and vascular biology, 29 7
T. Tang, S. Howarth, Sam Miller, M. Graves, A. Patterson, J. U-King-im, Z. Li, S. Walsh, Andrew Brown, P. Kirkpatrick, E. Warburton, P. Hayes, K. Varty, J. Boyle, M. Gaunt, A. Zalewski, J. Gillard (2009)
The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease.Journal of the American College of Cardiology, 53 22
A. Jacobson, R. Senior, M. Cerqueira, N. Wong, G. Thomas, Victor Lopez, D. Agostini, F. Weiland, H. Chandna, J. Narula (2010)
Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study.Journal of the American College of Cardiology, 55 20
Junwei Liu, K. Narsinh, F. Lan, Li Wang, P. Nguyen, Shijun Hu, A. Lee, Leng Han, Y. Gong, Mei Huang, Divya Nag, J. Rosenberg, A. Chouldechova, R. Robbins, Joseph Wu (2012)
Early Stem Cell Engraftment Predicts Late Cardiac Functional Recovery: Preclinical Insights From Molecular ImagingCirculation: Cardiovascular Imaging, 5
D. Meoli, M. Sadeghi, S. Krassilnikova, Brian Bourke, F. Giordano, D. Dione, Haili Su, D. Edwards, Shuang Liu, Thomas Harris, J. Madri, B. Zaret, A. Sinusas (2004)
Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction.The Journal of clinical investigation, 113 12
F. Schmitt, L. Lagopoulos, P. Kaeuper, N. Rossi, N. Busso, Jérôme Barge, G. Wagnières, C. Laue, C. Wandrey, L. Juillerat-Jeanneret (2010)
Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints.Journal of controlled release : official journal of the Controlled Release Society, 144 2
A. Shuhendler, Kanyi Pu, Lina Cui, J. Uetrecht, J. Rao (2014)
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testingNature biotechnology, 32
L. Winkel, H. Groen, B. Thiel, C. Müller, A. Steen, J. Wentzel, M. Jong, K. Heiden (2014)
Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stable Atherosclerotic Plaques?Molecular Imaging, 13
Amparo Figueroa, Amr Abdelbaky, Q. Truong, E. Corsini, Megan MacNabb, Zachary Lavender, M. Lawler, S. Grinspoon, T. Brady, K. Nasir, U. Hoffmann, A. Tawakol (2013)
Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events.JACC. Cardiovascular imaging, 6 12
E. Osborn, F. Jaffer (2015)
Imaging inflammation and neovascularization in atherosclerosis: clinical and translational molecular and structural imaging targetsCurrent Opinion in Cardiology, 30
(2010)
Molecular imaging of angiogenic therapy in peripheral vascular disease with alphanubeta3-integrin-targeted nanoparticles
C. Shim, Ya Liu, Tamara Atkinson, Aris Xie, T. Foster, Brian Davidson, Mackenzie Treible, Y. Qi, José López, A. Munday, Z. Ruggeri, J. Lindner (2015)
Molecular Imaging of Platelet–Endothelial Interactions and Endothelial von Willebrand Factor in Early and Mid-Stage AtherosclerosisCirculation: Cardiovascular Imaging, 8
F. Jaffer, Dong-Eog Kim, L. Quinti, C. Tung, E. Aikawa, Ashvin Pande, Rainer Kohler, G. Shi, P. Libby, R. Weissleder (2007)
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence SensorCirculation, 115
M. Friedrich, T. Karamitsos (2013)
Oxygenation-sensitive cardiovascular magnetic resonanceJournal of Cardiovascular Magnetic Resonance, 15
(2016)
FDA drug approvals
J. Luijn, F. Gribnau, H. Leufkens (2010)
Superior efficacy of new medicines?European Journal of Clinical Pharmacology, 66
S. Ruehm, C. Corot, P. Vogt, S. Kolb, J. Debatin (2001)
Magnetic Resonance Imaging of Atherosclerotic Plaque With Ultrasmall Superparamagnetic Particles of Iron Oxide in Hyperlipidemic RabbitsCirculation: Journal of the American Heart Association, 103
A. Tawakol, Z. Fayad, R. Mogg, Achilles Alon, M. Klimas, H. Dansky, S. Subramanian, Amr Abdelbaky, J. Rudd, M. Farkouh, Irene Nunes, C. Beals, S. Shankar (2013)
Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study.Journal of the American College of Cardiology, 62 10
Yani Liu, Brian Davidson, Qi Yue, T. Belcik, Aris Xie, Yoichi Inaba, O. McCarty, G. Tormoen, Yan Zhao, Z. Ruggeri, B. Kaufmann, J. Lindner (2013)
Molecular Imaging of Inflammation and Platelet Adhesion in Advanced Atherosclerosis Effects of Antioxidant Therapy With NADPH Oxidase InhibitionCirculation: Cardiovascular Imaging, 6
Jiasheng Zhang, L. Nie, Mahmoud Razavian, Masood Ahmed, L. Dobrucki, A. Asadi, D. Edwards, M. Azure, A. Sinusas, Mehran Sadeghi (2008)
Molecular Imaging of Activated Matrix Metalloproteinases in Vascular RemodelingCirculation, 118
E. Aikawa, M. Nahrendorf, D. Sosnovik, Vincent Lok, F. Jaffer, M. Aikawa, R. Weissleder (2007)
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve DiseaseCirculation, 115
R. Duivenvoorden, Jun Tang, D. Cormode, A. Mieszawska, D. Izquierdo-Garcia, C. Ozcan, Maarten Otten, N. Zaidi, M. Lobatto, Sarian Rijs, Bram Priem, Emma Kuan, C. Martel, B. Hewing, H. Sager, M. Nahrendorf, G. Randolph, E. Stroes, V. Fuster, E. Fisher, Z. Fayad, W. Mulder (2014)
A Statin-Loaded Reconstituted High-Density Lipoprotein Nanoparticle Inhibits Atherosclerotic Plaque InflammationNature communications, 5
Chad Carr, Y. Qi, Brian Davidson, S. Chadderdon, A. Jayaweera, J. Belcik, C. Benner, Aris Xie, Jonathan Lindner (2011)
Dysregulated Selectin Expression and Monocyte Recruitment During Ischemia-Related Vascular Remodeling in Diabetes MellitusArteriosclerosis, Thrombosis, and Vascular Biology, 31
S. Borne, S. Borne, S. Isobe, J. Verjans, A. Petrov, D. Løvhaug, Peng Li, H. Zandbergen, Y. Ni, P. Frederik, Jun Zhou, B. Arbo, A. Rogstad, A. Cuthbertson, S. Chettibi, C. Reutelingsperger, W. Blankesteijn, J. Smits, M. Daemen, F. Zannad, M. Vannan, N. Narula, B. Pitt, L. Hofstra, J. Narula (2008)
Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction.Journal of the American College of Cardiology, 52 24
K. Miller, Michael Lanthier (2016)
Trends In Orphan New Molecular Entities, 1983-2014: Half Were First In Class, And Rare Cancers Were The Most Frequent Target.Health affairs, 35 3
M. Settles, Martin Etzrodt, Katja Kosanke, M. Schiemann, A. Zimmermann, R. Meier, R. Braren, A. Huber, E. Rummeny, R. Weissleder, F. Swirski, M. Wildgruber (2011)
Different Capacity of Monocyte Subsets to Phagocytose Iron-Oxide NanoparticlesPLoS ONE, 6
M. Politis (2014)
Neuroimaging in Parkinson disease: from research setting to clinical practiceNature Reviews Neurology, 10
M. Nahrendorf, D. Sosnovik, B. French, F. Swirski, F. Bengel, M. Sadeghi, J. Lindner, Joseph Wu, D. Kraitchman, Z. Fayad, A. Sinusas (2008)
Advances in Cardiovascular Imaging Multimodality Cardiovascular Molecular Imaging, Part II
V. Lounnas, T. Ritschel, J. Kelder, R. McGuire, R. Bywater, N. Foloppe (2013)
Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discoveryComputational and Structural Biotechnology Journal, 5
L. Liberti, M. Bujar, A. Breckenridge, J. Hoekman, N. McAuslane, P. Stolk, H. Leufkens (2017)
FDA Facilitated Regulatory Pathways: Visualizing Their Characteristics, Development, and Authorization TimelinesFrontiers in Pharmacology, 8
J. Lindner, A. Sinusas (2013)
Molecular imaging in cardiovascular disease: Which methods, which diseases?Journal of Nuclear Cardiology, 20
Agnese Irkle, A. Vesey, David Lewis, J. Skepper, Joseph Bird, M. Dweck, Francis Joshi, Ferdia Gallagher, Elizabeth Warburton, Martin Bennett, Kevin Brindle, David Newby, J. Rudd, Anthony Davenport (2015)
Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomographyNature Communications, 6
E. Khanicheh, Martina Mitterhuber, Lifen Xu, Stéphanie Haeuselmann, G. Kuster, B. Kaufmann (2013)
Noninvasive Ultrasound Molecular Imaging of the Effect of Statins on Endothelial Inflammatory Phenotype in Early AtherosclerosisPLoS ONE, 8
Noninvasive imaging has played an increasing role in the process of cardiovascular drug development. This review focuses specifically on the use of molecular imaging, which has been increasingly applied to improve and accelerate certain preclinical steps in drug development, including the identification of appropriate therapeutic targets, evaluation of on-target and off-target effects of candidate therapies, assessment of dose response, and the evaluation of drug or biological biodistribution and pharmacodynamics. Unlike the case in cancer medicine, in cardiovascular medicine, molecular imaging has not been used as a primary surrogate clinical end point for drug approval. However, molecular imaging has been applied in early clinical trials, particularly in phase 0 studies, to demonstrate proof-of-concept or to explain variation in treatment effect. Many of these applications where molecular imaging has been used in drug development have involved the retasking of technologies that were originally intended as clinical diagnostics. With greater experience and recognition of the rich information provided by in vivo molecular imaging, it is anticipated that it will increasingly be used to address the enormous time and costs associated with bringing a new drug to clinical launch.
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Feb 1, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.