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Molecular Analysis of the KIT

Molecular Analysis of the KIT RESEARCH ARTICLE Molecular Analysis of the KIT Gene in Gastrointestinal Stromal Tumors With Novel Mutations Gizem Calibasi, MSc,* Yasemin Baskin, MD, PhD,* Hakan Alyuruk, MSc,w Levent Cavas, PhD,z Ilhan Oztop, MD,y Ozgul Sagol, MD,8 Koray Atila, MD,z Hulya Ellidokuz, MD,# and Ugur Yilmaz, MDy originate from the intestinal wall and function in the Abstract: Gastrointestinal stromal tumors (GISTs) are the most peristaltic movement of the gastrointestinal tract. GISTs common mesenchymal tumors of the gastrointestinal tract. KIT can develop at any site of the gastrointestinal system but gene mutations have great importance for GISTs. This study are primarily observed in the stomach (50% to 60%), evaluated the relationship between KIT mutations and GIST small intestine (20% to 30%), and large intestine (10%). clinicopathologic features to define region-specific and pop- Histologically, GISTs can consist of spindle (70%), epi- ulation-specific differences. Genomic DNA was extracted from thelioid (20%), and, rarely, mixed cell types. Tumor size 60 GISTs, and polymerase chain reaction was performed for and mitotic count are commonly used for prognostic risk KIT gene exons 9, 11, 13, and 17. Polymerase chain reaction classification systems. GISTs are classified as very low amplicons were sequenced in both directions. This study repre- risk, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318284a074
pmid
23455185
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Molecular Analysis of the KIT Gene in Gastrointestinal Stromal Tumors With Novel Mutations Gizem Calibasi, MSc,* Yasemin Baskin, MD, PhD,* Hakan Alyuruk, MSc,w Levent Cavas, PhD,z Ilhan Oztop, MD,y Ozgul Sagol, MD,8 Koray Atila, MD,z Hulya Ellidokuz, MD,# and Ugur Yilmaz, MDy originate from the intestinal wall and function in the Abstract: Gastrointestinal stromal tumors (GISTs) are the most peristaltic movement of the gastrointestinal tract. GISTs common mesenchymal tumors of the gastrointestinal tract. KIT can develop at any site of the gastrointestinal system but gene mutations have great importance for GISTs. This study are primarily observed in the stomach (50% to 60%), evaluated the relationship between KIT mutations and GIST small intestine (20% to 30%), and large intestine (10%). clinicopathologic features to define region-specific and pop- Histologically, GISTs can consist of spindle (70%), epi- ulation-specific differences. Genomic DNA was extracted from thelioid (20%), and, rarely, mixed cell types. Tumor size 60 GISTs, and polymerase chain reaction was performed for and mitotic count are commonly used for prognostic risk KIT gene exons 9, 11, 13, and 17. Polymerase chain reaction classification systems. GISTs are classified as very low amplicons were sequenced in both directions. This study repre- risk,

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2014

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