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Microbiome and skin diseases

Microbiome and skin diseases REVIEW URRENT PINION a b c Patrick L.J.M. Zeeuwen , Michiel Kleerebezem , Harro M. Timmerman , and Joost Schalkwijk Purpose of review This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases. Recent findings Advances in computing and high-throughput sequencing technology have enabled in-depth analysis of microbiota composition and functionality of human skin. Most data generated to date are related to the skin microbiome of healthy volunteers, but recent studies have also addressed the dynamics of the microbiome in diseased and injured skin. Currently, reports are emerging that evaluate the strategies to manipulate the skin microbiome, intending to modulate diseases and/or their symptoms. Summary The microbiome of normal human skin was found to have a high diversity and high interpersonal variation. Microbiota compositions of diseased lesional skin (in atopic dermatitis and psoriasis) showed distinct differences compared with healthy skin. The function of microbial colonization in establishing immune system homeostasis has been reported, whereas host–microbe interactions and genetically determined variation of stratum corneum properties might be linked to skin dysbiosis. Both are relevant for cutaneous disorders with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Microbiome and skin diseases

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Copyright
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e328364ebeb
pmid
23974680
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT PINION a b c Patrick L.J.M. Zeeuwen , Michiel Kleerebezem , Harro M. Timmerman , and Joost Schalkwijk Purpose of review This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases. Recent findings Advances in computing and high-throughput sequencing technology have enabled in-depth analysis of microbiota composition and functionality of human skin. Most data generated to date are related to the skin microbiome of healthy volunteers, but recent studies have also addressed the dynamics of the microbiome in diseased and injured skin. Currently, reports are emerging that evaluate the strategies to manipulate the skin microbiome, intending to modulate diseases and/or their symptoms. Summary The microbiome of normal human skin was found to have a high diversity and high interpersonal variation. Microbiota compositions of diseased lesional skin (in atopic dermatitis and psoriasis) showed distinct differences compared with healthy skin. The function of microbial colonization in establishing immune system homeostasis has been reported, whereas host–microbe interactions and genetically determined variation of stratum corneum properties might be linked to skin dysbiosis. Both are relevant for cutaneous disorders with

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Oct 1, 2013

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