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Microbicide safety/efficacy studies in animals: macaques and small animal models

Microbicide safety/efficacy studies in animals: macaques and small animal models Microbicide safety/efficacy studies in animals: macaques and small animal models Ronald S. Veazey Tulane National Primate Research Center, Tulane Purpose of review University School of Medicine, Covington, Louisiana, A number of microbicide candidates have failed to prevent HIV transmission in human USA clinical trials, and there is uncertainty as to how many additional trials can be supported Correspondence to Ronald S. Veazey, Tulane National by the field. Regardless, there are far too many microbicide candidates in development, Primate Research Center, Tulane University School of Medicine, 187043 Three Rivers Road, Covington, and a logical and consistent method for screening and selecting candidates for human LA 70433, USA clinical trials is desperately needed. The unique host and cell specificity of HIV, however, Tel: +1 985 871 6228; e-mail: rveazey@tulane.edu provides challenges for microbicide safety and efficacy screening, that can only be addressed by rigorous testing in relevant laboratory animal models. Current Opinion in HIV and AIDS 2008, 3:567– Recent findings A number of laboratory animal model systems ranging from rodents to nonhuman primates, and single versus multiple dose challenges have recently been developed to test microbicide candidates. These models have shed light on both the safety and efficacy of candidate microbicides http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Microbicide safety/efficacy studies in animals: macaques and small animal models

Veazey, Ronald S
Current Opinion in HIV and Aids , Volume 3 (5) – Sep 1, 2008
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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e32830891bb
pmid
19373023
Publisher site
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Abstract

Microbicide safety/efficacy studies in animals: macaques and small animal models Ronald S. Veazey Tulane National Primate Research Center, Tulane Purpose of review University School of Medicine, Covington, Louisiana, A number of microbicide candidates have failed to prevent HIV transmission in human USA clinical trials, and there is uncertainty as to how many additional trials can be supported Correspondence to Ronald S. Veazey, Tulane National by the field. Regardless, there are far too many microbicide candidates in development, Primate Research Center, Tulane University School of Medicine, 187043 Three Rivers Road, Covington, and a logical and consistent method for screening and selecting candidates for human LA 70433, USA clinical trials is desperately needed. The unique host and cell specificity of HIV, however, Tel: +1 985 871 6228; e-mail: rveazey@tulane.edu provides challenges for microbicide safety and efficacy screening, that can only be addressed by rigorous testing in relevant laboratory animal models. Current Opinion in HIV and AIDS 2008, 3:567– Recent findings A number of laboratory animal model systems ranging from rodents to nonhuman primates, and single versus multiple dose challenges have recently been developed to test microbicide candidates. These models have shed light on both the safety and efficacy of candidate microbicides

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Sep 1, 2008

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