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- Publisher
- Wolters Kluwer Health
- Copyright
- Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
- ISSN
- 1746-630X
- eISSN
- 1746-6318
- DOI
- 10.1097/COH.0000000000000424
- pmid
- 29028666
- Publisher site
- See Article on Publisher Site
Abstract
Purpose of reviewThe article describes recent advances in understanding the causes and consequences of microbial translocation in HIV and simian immunodeficiency virus infections.Recent findingsPersistent microbial translocation contributes to aberrant immune activation in immunodeficiency lentiviral infections and thereby, pathogenesis and mortality. Efforts to delineate the circumstances surrounding translocation have benefited from use of simian immunodeficiency virus-infected nonhuman primates and highlight the overwhelming immunologic diversion caused by translocating microbes. The use of therapeutics aimed at reducing microbial translocation show promise and will benefit from continued research into the mechanisms that promote systemic microbial dissemination in treated and untreated infections.SummaryInsights into the source and identity of translocating microbes in lentiviral infections continue to enhance the development of adjunct therapeutics.
Journal
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Jan 1, 2018