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Metallothionein Immunolocalization in Actinic Skin Nonmelanoma Carcinomas

Metallothionein Immunolocalization in Actinic Skin Nonmelanoma Carcinomas RESEARCH ARTICLE Metallothionein Immunolocalization in Actinic Skin Nonmelanoma Carcinomas Paulo C. Borges Ju´nior, DDS, MS, Rosy I. M. A. Ribeiro, BS, MSB, Sergio V. Cardoso, DDS, PhD, Alceu L. C. Berbet, MD, MS, Ademir Rocha, MD, PhD, Foued S. Espindola, BS, PhD, and Adriano M. Loyola, DDS, PhD expression of this protein seems to be associated to Abstract: Basal cell carcinoma (BCC) and squamous cell anticarcinogenic effect, whereas increased expression and carcinoma (SCC) are the most frequent skin cancer. Its specific biologic protective roles for this protein have been pathogeny is linked to genotoxic effects of actinic radiation observed in cells and tissues submitted to ionizing 3–5 exposure, especially to ultraviolet wavelength. Metallothionein radiation. Recent evidence has proposed roles for (MT) is a low-molecular weight protein with high affinity for MT in cell proliferation and p53-mediated DNA vigi- 6–8 heavy metal. Its intracellular function has been related to heavy lance. Thus, MT is likely a key mediator at the initial metals and free-radical detoxification, although many studies stages of carcinogenesis, with relevant cellular protective linked MT to protective action against actinic mutagenesis. In functions. On another side, its detoxication role against other way, overexpression in malignant tumors has been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Metallothionein Immunolocalization in Actinic Skin Nonmelanoma Carcinomas

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ISSN
1541-2016
DOI
10.1097/01.pai.0000213115.27978.73
pmid
17525628
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Metallothionein Immunolocalization in Actinic Skin Nonmelanoma Carcinomas Paulo C. Borges Ju´nior, DDS, MS, Rosy I. M. A. Ribeiro, BS, MSB, Sergio V. Cardoso, DDS, PhD, Alceu L. C. Berbet, MD, MS, Ademir Rocha, MD, PhD, Foued S. Espindola, BS, PhD, and Adriano M. Loyola, DDS, PhD expression of this protein seems to be associated to Abstract: Basal cell carcinoma (BCC) and squamous cell anticarcinogenic effect, whereas increased expression and carcinoma (SCC) are the most frequent skin cancer. Its specific biologic protective roles for this protein have been pathogeny is linked to genotoxic effects of actinic radiation observed in cells and tissues submitted to ionizing 3–5 exposure, especially to ultraviolet wavelength. Metallothionein radiation. Recent evidence has proposed roles for (MT) is a low-molecular weight protein with high affinity for MT in cell proliferation and p53-mediated DNA vigi- 6–8 heavy metal. Its intracellular function has been related to heavy lance. Thus, MT is likely a key mediator at the initial metals and free-radical detoxification, although many studies stages of carcinogenesis, with relevant cellular protective linked MT to protective action against actinic mutagenesis. In functions. On another side, its detoxication role against other way, overexpression in malignant tumors has been

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jun 1, 2007

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