Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
RESEARCH ARTICLE Merkel Cell Polyomavirus is Not Detected in Lung Adenocarcinomas by Immunohistochemistry Humberto E. Trejo Bittar, MD and Liron Pantanowitz, MD tection of MCPyV in lung carcinomas, with a reported Abstract: Merkel cell polyomavirus (MCPyV) is an oncogenic prevalence that ranges from 0% to as high as 20% in DNA virus that causes Merkel cell carcinoma. Recently, MCPyV some small series of lung adenocarcinomas. One study has been identified in other noncutaneous tumors including lung suggests an association of MCPyV detection with epi- non–small cell carcinoma. However, the true role of this virus in thelial growth factor receptor (EGFR) mutation status. lung carcinogenesis is unclear. We aimed to determine the efficacy The causal role of this virus in lung carcinogenesis is of immunohistochemistry for detecting MCPyV in a series of lung 4–7 currently unclear. adenocarcinomas. Nuclear expression of the MCPyV large T an- A majority of studies examining MCPyV in lung tigen was evaluated by immunohistochemistry (CM2B4 antibody) cancer uses polymerase chain reaction (PCR) to de- in formalin-fixed paraffin-embedded lung adenocarcinomas of dif- termine the presence of this virus. However, beacuse of ferent histologic subtypes. Of a total of 90 lung adenocarcinomas the near-ubiquitous nature of infection by
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Aug 1, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.