Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Merkel Cell Polyomavirus is Not Detected in Lung Adenocarcinomas by Immunohistochemistry

Merkel Cell Polyomavirus is Not Detected in Lung Adenocarcinomas by Immunohistochemistry RESEARCH ARTICLE Merkel Cell Polyomavirus is Not Detected in Lung Adenocarcinomas by Immunohistochemistry Humberto E. Trejo Bittar, MD and Liron Pantanowitz, MD tection of MCPyV in lung carcinomas, with a reported Abstract: Merkel cell polyomavirus (MCPyV) is an oncogenic prevalence that ranges from 0% to as high as 20% in DNA virus that causes Merkel cell carcinoma. Recently, MCPyV some small series of lung adenocarcinomas. One study has been identified in other noncutaneous tumors including lung suggests an association of MCPyV detection with epi- non–small cell carcinoma. However, the true role of this virus in thelial growth factor receptor (EGFR) mutation status. lung carcinogenesis is unclear. We aimed to determine the efficacy The causal role of this virus in lung carcinogenesis is of immunohistochemistry for detecting MCPyV in a series of lung 4–7 currently unclear. adenocarcinomas. Nuclear expression of the MCPyV large T an- A majority of studies examining MCPyV in lung tigen was evaluated by immunohistochemistry (CM2B4 antibody) cancer uses polymerase chain reaction (PCR) to de- in formalin-fixed paraffin-embedded lung adenocarcinomas of dif- termine the presence of this virus. However, beacuse of ferent histologic subtypes. Of a total of 90 lung adenocarcinomas the near-ubiquitous nature of infection by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Merkel Cell Polyomavirus is Not Detected in Lung Adenocarcinomas by Immunohistochemistry

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Aug 1, 2015

Loading next page...
 
/lp/wolters-kluwer-health/merkel-cell-polyomavirus-is-not-detected-in-lung-adenocarcinomas-by-N2YcBNh1en
Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000210
pmid
26317307
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Merkel Cell Polyomavirus is Not Detected in Lung Adenocarcinomas by Immunohistochemistry Humberto E. Trejo Bittar, MD and Liron Pantanowitz, MD tection of MCPyV in lung carcinomas, with a reported Abstract: Merkel cell polyomavirus (MCPyV) is an oncogenic prevalence that ranges from 0% to as high as 20% in DNA virus that causes Merkel cell carcinoma. Recently, MCPyV some small series of lung adenocarcinomas. One study has been identified in other noncutaneous tumors including lung suggests an association of MCPyV detection with epi- non–small cell carcinoma. However, the true role of this virus in thelial growth factor receptor (EGFR) mutation status. lung carcinogenesis is unclear. We aimed to determine the efficacy The causal role of this virus in lung carcinogenesis is of immunohistochemistry for detecting MCPyV in a series of lung 4–7 currently unclear. adenocarcinomas. Nuclear expression of the MCPyV large T an- A majority of studies examining MCPyV in lung tigen was evaluated by immunohistochemistry (CM2B4 antibody) cancer uses polymerase chain reaction (PCR) to de- in formalin-fixed paraffin-embedded lung adenocarcinomas of dif- termine the presence of this virus. However, beacuse of ferent histologic subtypes. Of a total of 90 lung adenocarcinomas the near-ubiquitous nature of infection by

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Aug 1, 2015

There are no references for this article.