Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
We examined four melanotic neuroectodermal tumors (three jaw, one epididymis) of infancy (MNTI) by the immunoperoxidase method for intermediate filament-, neuroendocrine-, and melanoma-associated antigen profiles comparing these immunoreactions with those of 10 pediatric neuroblastomas, five retinoblastomas, and five retinas. Three MNTIs had larger pigmented epithelioid cells and small neuroblastic cells; one was composed mainly of pigmented epithelioid cells. One or more melanoma-associated antigens (HMB-45, HMB-50) and cytokeratin were consistently expressed in the large cells (four of four). The small cells stained for neuron-specific enolase (two of three) and synaptophysin (two of three). Neurofilament- and microtubular-associated proteins were demonstrated in the frozen tissue of one tumor. Both cell types were positive for vimentin, while negative for chromogranin A and S-100. Variable numbers of cells expressed desmin in one case, and muscle-specific actin in two cases. In contrast, neuroblastoma and retinoblastomas stained variably for vimentin, neuron-specific enolase, synaptophysin, and chromogranin. Neither tumor contained melanoma-associated antigens or cytokeratin. Pigment epithelium of the retina coexpressed cytokeratin and melanoma-associated antigens but lacked S-100. The results show that MNTI is a distinctive primitive neoplasm with a polyphenotypic profile of epithelial, neuroblastic, melanin-producing, and mesenchymal differentiation. Melanocytic differentiation in MNTI is distinguished from melanoma by lack of S-100 protein with consistent expression of cytokeratin. Myogenic differentiation in MNTI is a potential source of confusion with rhabdomyosarcomas, especially in small biopsy specimens. Coexpression of cytokeratin and melanoma-associated antigens by pigment-containing cells is similar to that of retinal pigment epithelium.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jan 1, 1993
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.