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Mediation Effect of Left Ventricular Geometric Adaptation to Lifetime Blood Pressure on Cognitive Function in Middle-Age

Mediation Effect of Left Ventricular Geometric Adaptation to Lifetime Blood Pressure on Cognitive... Circulation: Cardiovascular Imaging EDITORIAL Mediation Effect of Left Ventricular Geometric Adaptation to Lifetime Blood Pressure on Cognitive Function in Middle-Age The Heart-Brain Connection (Partially) Explained See Article by Razavi et al Jonathan N. Bella , MD everal studies have shown that measures of cardiac target organ damage are 1–4 independent predictors of increased cardiovascular morbidity and mortality. SLeft ventricular (LV) hypertrophy was one of the first measures of cardiac tar - get organ damage to have been shown to predict adverse cardiac events in clinical 1,2 and population-based samples. Subsequently, other measures of cardiac target organ damage have been implicated in predicting adverse outcomes in clinical 3,4 and population-based populations. More recently, studies have indicated that LV hypertrophy is independently associated with impaired cognitive function and 5,6 7 dementia in older adults 60 years and older. The present study by Razavi et al extends these results by showing that LV geometric remodeling partially mediates the association between lifetime systolic blood pressure (BP) and cognitive func- tion in younger adults (mean age=48 years) without clinical dementia or cardio- 2.7 vascular disease. They found that for each g/m increase in LV mass index, there was an associated 0.03 standardized unit decrease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Mediation Effect of Left Ventricular Geometric Adaptation to Lifetime Blood Pressure on Cognitive Function in Middle-Age

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Publisher
Wolters Kluwer Health
Copyright
© 2020 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.120.011325
Publisher site
See Article on Publisher Site

Abstract

Circulation: Cardiovascular Imaging EDITORIAL Mediation Effect of Left Ventricular Geometric Adaptation to Lifetime Blood Pressure on Cognitive Function in Middle-Age The Heart-Brain Connection (Partially) Explained See Article by Razavi et al Jonathan N. Bella , MD everal studies have shown that measures of cardiac target organ damage are 1–4 independent predictors of increased cardiovascular morbidity and mortality. SLeft ventricular (LV) hypertrophy was one of the first measures of cardiac tar - get organ damage to have been shown to predict adverse cardiac events in clinical 1,2 and population-based samples. Subsequently, other measures of cardiac target organ damage have been implicated in predicting adverse outcomes in clinical 3,4 and population-based populations. More recently, studies have indicated that LV hypertrophy is independently associated with impaired cognitive function and 5,6 7 dementia in older adults 60 years and older. The present study by Razavi et al extends these results by showing that LV geometric remodeling partially mediates the association between lifetime systolic blood pressure (BP) and cognitive func- tion in younger adults (mean age=48 years) without clinical dementia or cardio- 2.7 vascular disease. They found that for each g/m increase in LV mass index, there was an associated 0.03 standardized unit decrease

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Aug 1, 2020

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