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RESEARCH ARTICLE Mean Nuclear Area and Metallothionein Expression in Ductal Breast Tumors: Correlation With Estrogen Receptor Status Sonia L. El Sharkawy, MD and Abdel Razik H. Farrag, PhD reast carcinoma is the most common malignancy in Abstract: Breast carcinoma is the most common malignancy in Bwomen and the incidence of ductal carcinoma in situ women. Estrogen is an important growth factor for breast (DCIS), which represents the immediate preinvasive stage tumor that plays an important role in regulating the prolifera- of breast carcinoma, is increasing each year. Estrogen, tion and differentiation of normal and malignant mammary progesterone, and prolactin-mediate progression of the epithelial cells. Nuclear morphometry and metallothioneins rudimentary ductal system present at birth to an extensive (MTs) are indicators of proliferation that have been used as network after puberty and finally into a differentiated predictors of prognosis in many tumors. The present study milk-producing organ during pregnancy and lactation. aimed to study mean nuclear area (MNA) and MT; estrogen These hormones also regulate the occurrence and timing receptor (ER) expression in fibroadenoma (FA), ductal carci- of reproductive events that influence a woman’s risk of noma in situ (DCIS), and infiltrating ductal carcinoma (IDC) of developing breast cancer. the
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2008
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