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Mast cells: makers and breakers of allergic inflammation

Mast cells: makers and breakers of allergic inflammation Mast cells: makers and breakers of allergic inflammation Kayvan Hakim-Rad, Martin Metz and Marcus Maurer Department of Dermatology and Allergy, Allergie- Purpose of review Centrum-Charite´/ECARF, Charite´ -Universita¨tsmedizin Recent findings have developed, changed, challenged and extended the established Berlin, Berlin, Germany view of mast cell biology and of their role in inflammation. The purpose of this review is to Correspondence to Marcus Maurer, MD, Professor of present and discuss recent research in this area relating to allergic inflammation. Dermatology and Allergy, Department of Dermatology and Allergy, Allergie-Centrum-Charite´ , Charite´- Recent findings Universita¨tsmedizin Berlin, Charite´ platz 1, 10117 Mast cells are traditionally viewed only as IgE-activated histamine-providing effector Berlin, Germany Tel: +49 30 450 518 043; fax: +49 30 450 518 972; cells of allergic inflammation. Yet, recent findings also support a role for mast cells in the e-mail: marcus.maurer@charite.de sensitization to allergens, and early released human mast cell tryptase has been shown Current Opinion in Allergy and Clinical to break down IgE, hence breaking the key maker of allergic inflammation. Furthermore, Immunology 2009, 9:427–430 mast cells demonstrate proinflammatory action through nonhistamine and non-IgE- mediated routes. For example, the role of platelet-activating factor in contributing to allergic inflammation and anaphylaxis in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Mast cells: makers and breakers of allergic inflammation

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References (36)

ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e32832e9af1
pmid
19550301
Publisher site
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Abstract

Mast cells: makers and breakers of allergic inflammation Kayvan Hakim-Rad, Martin Metz and Marcus Maurer Department of Dermatology and Allergy, Allergie- Purpose of review Centrum-Charite´/ECARF, Charite´ -Universita¨tsmedizin Recent findings have developed, changed, challenged and extended the established Berlin, Berlin, Germany view of mast cell biology and of their role in inflammation. The purpose of this review is to Correspondence to Marcus Maurer, MD, Professor of present and discuss recent research in this area relating to allergic inflammation. Dermatology and Allergy, Department of Dermatology and Allergy, Allergie-Centrum-Charite´ , Charite´- Recent findings Universita¨tsmedizin Berlin, Charite´ platz 1, 10117 Mast cells are traditionally viewed only as IgE-activated histamine-providing effector Berlin, Germany Tel: +49 30 450 518 043; fax: +49 30 450 518 972; cells of allergic inflammation. Yet, recent findings also support a role for mast cells in the e-mail: marcus.maurer@charite.de sensitization to allergens, and early released human mast cell tryptase has been shown Current Opinion in Allergy and Clinical to break down IgE, hence breaking the key maker of allergic inflammation. Furthermore, Immunology 2009, 9:427–430 mast cells demonstrate proinflammatory action through nonhistamine and non-IgE- mediated routes. For example, the role of platelet-activating factor in contributing to allergic inflammation and anaphylaxis in

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Oct 1, 2009

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