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Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms

Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms RESEARCH ARTICLE Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms Markku Miettinen, MD,* Maarit Sarlomo-Rikala, MD,w Peter McCue, MD,z Piotr Czapiewski, MD,y Renata Langfort, MD,8 Piotr Waloszczyk, MD,z Krzysztof Wazny, MD,y Wojciech Biernat, MD,y Jerzy Lasota, MD,* and Zengfeng Wang, PhD* Key Words: succinate dehydrogenase subunit B, SDHB, renal Abstract: Losses in the succinate dehydrogenase (SDH) complex cell carcinoma, prostatic carcinoma, gastric lymphoepithelial characterize 20% to 30% of extra-adrenal paragangliomas and carcinoma, seminoma 7% to 8% of gastric GISTs, and rare renal cell carcinomas. This (Appl Immunohistochem Mol Morphol 2014;22:31–36) loss is reflected as lack of the normally ubiquitous im- munohistochemical expression of the SDH subunit B (SDHB). In paragangliomas, SDHB loss correlates with homozygous loss of any of the SDH subunits, typically by loss-of-function mu- tations. The occurrence of SDHB losses in other epithelial ma- uccinate dehydrogenase (SDH) is a key hetero- lignancies is unknown. In this study, we immunohistochemically Stetrameric enzyme complex of the energy metabolism examined 2258 epithelial, mostly malignant neoplasms including located in the mitochondrial inner membrane and in- common carcinomas of all sites. Among renal cell carcinomas, volved in the Krebs cycle and oxidative phosphorylation. SDHB loss was observed in 4 of 711 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31828bfdd3
pmid
23531856
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms Markku Miettinen, MD,* Maarit Sarlomo-Rikala, MD,w Peter McCue, MD,z Piotr Czapiewski, MD,y Renata Langfort, MD,8 Piotr Waloszczyk, MD,z Krzysztof Wazny, MD,y Wojciech Biernat, MD,y Jerzy Lasota, MD,* and Zengfeng Wang, PhD* Key Words: succinate dehydrogenase subunit B, SDHB, renal Abstract: Losses in the succinate dehydrogenase (SDH) complex cell carcinoma, prostatic carcinoma, gastric lymphoepithelial characterize 20% to 30% of extra-adrenal paragangliomas and carcinoma, seminoma 7% to 8% of gastric GISTs, and rare renal cell carcinomas. This (Appl Immunohistochem Mol Morphol 2014;22:31–36) loss is reflected as lack of the normally ubiquitous im- munohistochemical expression of the SDH subunit B (SDHB). In paragangliomas, SDHB loss correlates with homozygous loss of any of the SDH subunits, typically by loss-of-function mu- tations. The occurrence of SDHB losses in other epithelial ma- uccinate dehydrogenase (SDH) is a key hetero- lignancies is unknown. In this study, we immunohistochemically Stetrameric enzyme complex of the energy metabolism examined 2258 epithelial, mostly malignant neoplasms including located in the mitochondrial inner membrane and in- common carcinomas of all sites. Among renal cell carcinomas, volved in the Krebs cycle and oxidative phosphorylation. SDHB loss was observed in 4 of 711

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2014

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