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ORIGINAL ARTICLE Many Patients 80 Years and Older with Advanced Non-small Cell Lung Cancer (NSCLC) Can Tolerate Chemotherapy Ozden Altundag, MD,* David J. Stewart, MD,* Frank V. Fossella, MD,* Gregory D. Ayers, MS,† Wei Wei, MS,† Xian Zhou, PhD,† and Ralph G. Zinner, MD* advanced NSCLC has been learned from studies of patients Abstract: People 80 years of age and older constitute 17.8% of all largely younger than 70 years old. lung cancer patients in the United States. Because the life expect- Platinum-based chemotherapy has been shown to both ancies of 80-year-old men and women are 87.3 years and 89.0 years, increase overall survival and improve the quality of life in respectively, non-small cell lung cancer shortens lives in addition to 3,4 patients with an adequate performance status (PS). A recent causing morbidity. In this retrospective study, all patients with study showed that bevacizumab improves survival when chemotherapy-naive advanced non-small cell lung cancer 80 years added to paclitaxel/carboplatin in patients with nonsquamous of age and older treated at the M. D. Anderson Cancer Center with NSCLC. Additionally, second-line agents such as docetaxel one or more follow-ups were identified from the database for the 6,7 and pemetrexed improve survival and
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Feb 1, 2007
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