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LWW/AENJ AENJ3004˙08REV October 21, 2008 21:18 Char Count= 0 Advanced Emergency Nursing Journal Vol. 30, No. 4, pp. 303–309 Copyright c 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins APPLIED Pharmacology Column Editor: Christopher M. Scott, PharmD, BCPS Management of Serotonin Syndrome Clinical Considerations Laura Aykroyd, PharmD, BCPS ; Pamela L. Walker, PharmD, BCPS EROTONIN SYNDROME, previously ten reported in the setting of medication in- known as serotonin toxicity, is a prod- teractions, there remains the potential for a Suct of over stimulation or agonism at the single agent to be the sole causative agent postsynaptic central nervous system (CNS) (Gill, LoVecchio, & Selden, 1999; Kaminski, serotonin receptors (Buck, 2006; Dunkley, Santeiro Robbins, & Weibley, 1994; Rosebush, Isbister, Sibbritt, Dawson, & Whyte, 2003; Margetts, & Mazurek, 1999). Predictably, Martin, 1996; Sternbach, 1991). This toxicity MAOIs, serotonin agonists, tricyclic antide- was first reported in humans in the 1960s pressants, and antimigraine medications (trip- as a result of medication interactions that tans) are frequently determined to be the commonly included a monoamine oxidase offending agents. Since the advent of a selec- inhibitor (MAOI) antidepressant in combina- tive serotonin reuptake inhibitor (SSRI) class tion with L-tryptohan (Martin, 1996; Prator, of medications
Advanced Emergency Nursing Journal – Wolters Kluwer Health
Published: Oct 1, 2008
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