Access the full text.
Sign up today, get DeepDyve free for 14 days.
N Mahr, Y Bouhake, G Chopard (2021)
Postoperative neurocognitive disorders after closed-loop versus manual target controlled-infusion of propofol and remifentanil in patients undergoing elective major noncardiac surgery: the randomized controlled POCD-ELA trial., 133
Mahr (2021)
837–847Anesth Analg, 133
Cover Editor and Illustrator (Including Infographics) Infographics Postoperative cognitive dysfunction (POCD) is an unfortunate reality for many patients after surgery Abbreviation: BIS = bispectral index, POCD, postoperative cognitive dysfunction. and is multifactorial in etiology. The total anesthetic burden endured during the surgical procedure is clearly one variable that may impact the incidence and severity of POCD. Authors in this issue The Infographic is composed by Naveen Nathan, MD, Northwestern University Feinberg School of of Anesthesia & Analgesia asked whether the titration of intravenous anesthetics through closed- Medicine (n-nathan@northwestern.edu). Illustration by Naveen Nathan, MD. loop infusion might lower the total anesthetic delivered and offer the benefit of decreased POCD. Over 200 patients were randomized to either manual adjustment of propofol and remifentanil infu- The author declares no conflicts of interest. sions versus closed-loop titrations for noncardiac surgery. As this infographic shows, no difference in POCD was found between the 2 groups. This finding could be explained by multiple factors such as REFERENCE the power to detect POCD given the sample size, the tools used to define POCD, and the fact that remifentanil decreases the required amount of anesthetic in general. A multitude of other factors 1. Mahr N, Bouhake Y, Chopard G, et al. Postoperative neurocognitive disorders after closed-loop could also have influenced these results and are addressed in their discussion. Interestingly, the total versus manual target controlled-infusion of propofol and remifentanil in patients undergoing elec- amount of propofol used was lower for patients on closed-loop infusions versus manual administra- tive major noncardiac surgery: the randomized controlled Postoperative Cognitive Dysfunction- tion. Further studies are required to further explore the utility of closed-loop infusions and outcomes. Electroencephalographic-Guided Anesthetic Adminstration trial. Anesth Analg. 2021;133:837–847. Copyright © 2021 International Anesthesia Research Society 836 www.anesthesia-analgesia.org October 2021 Volume 133 Number 4 • • Copyright © 2021 International Anesthesia Research Society. Unauthorized reproduction of this article is prohibited. Reprints will not be available from the author.
Anesthesia & Analgesia – Wolters Kluwer Health
Published: Oct 14, 2021
You can share this free article with as many people as you like with the url below! We hope you enjoy this feature!
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.