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Mammaglobin-A Immunohistochemistry in Primary Central Nervous System Neoplasms and Intracranial Metastatic Breast Carcinoma

Mammaglobin-A Immunohistochemistry in Primary Central Nervous System Neoplasms and Intracranial... RESEARCH ARTICLE Mammaglobin-A Immunohistochemistry in Primary Central Nervous System Neoplasms and Intracranial Metastatic Breast Carcinoma Patrick J. Cimino, Jr, MD, PhD and Richard J. Perrin, MD, PhD or meningioma, approximately half represent metastasis. Abstract: Metastases represent the most common type of intra- In women, breast carcinoma accounts for approximately cranial neoplasm. In women, 30% of such tumors derive from 30% of brain metastases. Not uncommonly, such meta- breast carcinoma. In neurosurgical cases with ambiguous cellular static tumors are the presenting feature of the primary morphology and/or limited biopsy material, immunohistochemistry neoplasm. Because primary and metastatic tumors can be (IHC) is often performed to distinguish metastases from primary histologically protean, and neurosurgical biopsy often central nervous system (CNS) neoplasms. IHC for mammaglobin- provides limited tissue for histomorphologic character- A (MGA), a protein expressed in a majority of breast carcinomas, ization, diagnosis often rests heavily upon ancillary is commonly applied in this setting, but its utility for distinguishing techniques, such as immunohistochemistry (IHC). Al- primary CNS neoplasms from metastatic breast carcinoma is though some markers of breast carcinoma [eg, gross unknown; the reactivity of MGA in primary and metastatic CNS cystic disease fluid protein-15 (GCDFP-15), estrogen neoplasms has never been described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Mammaglobin-A Immunohistochemistry in Primary Central Nervous System Neoplasms and Intracranial Metastatic Breast Carcinoma

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318294ca46
pmid
23958549
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Mammaglobin-A Immunohistochemistry in Primary Central Nervous System Neoplasms and Intracranial Metastatic Breast Carcinoma Patrick J. Cimino, Jr, MD, PhD and Richard J. Perrin, MD, PhD or meningioma, approximately half represent metastasis. Abstract: Metastases represent the most common type of intra- In women, breast carcinoma accounts for approximately cranial neoplasm. In women, 30% of such tumors derive from 30% of brain metastases. Not uncommonly, such meta- breast carcinoma. In neurosurgical cases with ambiguous cellular static tumors are the presenting feature of the primary morphology and/or limited biopsy material, immunohistochemistry neoplasm. Because primary and metastatic tumors can be (IHC) is often performed to distinguish metastases from primary histologically protean, and neurosurgical biopsy often central nervous system (CNS) neoplasms. IHC for mammaglobin- provides limited tissue for histomorphologic character- A (MGA), a protein expressed in a majority of breast carcinomas, ization, diagnosis often rests heavily upon ancillary is commonly applied in this setting, but its utility for distinguishing techniques, such as immunohistochemistry (IHC). Al- primary CNS neoplasms from metastatic breast carcinoma is though some markers of breast carcinoma [eg, gross unknown; the reactivity of MGA in primary and metastatic CNS cystic disease fluid protein-15 (GCDFP-15), estrogen neoplasms has never been described.

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jul 1, 2014

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