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Malignant Transformation in Von-Meyenburg Complexes Histologic and Immunohistochemical Clues With Illustrative Cases

Malignant Transformation in Von-Meyenburg Complexes Histologic and Immunohistochemical Clues... REVIEW ARTICLE Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases Vishwas Parekh, MD and Deniz Peker, MD Despite high prevalence of VMCs in population, Abstract: Benign developmental defects known as Von-Meyen- very few examples of malignant transformation of VMCs burg complexes (VMCs) have been postulated to progress to 7–25 to cholangiocarcinoma (CC) have been reported cholangiocarcinoma (CC) in rare instances. Although a gradual, (Table 1). Understandably, because of small number of sequential histologic transition from VMCs to CC has been cases to work with, most of these reports implicate VMCs described in some of these cases, the underlying genetic mech- in CC development through guilt-by-association rather anism is yet to be elucidated. Here, we review the literature to than cause and effect. Although simultaneity of VMCs put together a report on the clinicopathologic features and im- and CC in the same liver is suggestive of transition, munohistochemical changes associated with such trans- documenting such a transition to be taking place within formation. We also review the documented association between single ductular units would provide a stronger evidence INK4a CC and p16 inactivation, and discuss a possible role for this for VMC to CC transformation. In http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Malignant Transformation in Von-Meyenburg Complexes Histologic and Immunohistochemical Clues With Illustrative Cases

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Mar 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000132
pmid
25789533
Publisher site
See Article on Publisher Site

Abstract

REVIEW ARTICLE Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases Vishwas Parekh, MD and Deniz Peker, MD Despite high prevalence of VMCs in population, Abstract: Benign developmental defects known as Von-Meyen- very few examples of malignant transformation of VMCs burg complexes (VMCs) have been postulated to progress to 7–25 to cholangiocarcinoma (CC) have been reported cholangiocarcinoma (CC) in rare instances. Although a gradual, (Table 1). Understandably, because of small number of sequential histologic transition from VMCs to CC has been cases to work with, most of these reports implicate VMCs described in some of these cases, the underlying genetic mech- in CC development through guilt-by-association rather anism is yet to be elucidated. Here, we review the literature to than cause and effect. Although simultaneity of VMCs put together a report on the clinicopathologic features and im- and CC in the same liver is suggestive of transition, munohistochemical changes associated with such trans- documenting such a transition to be taking place within formation. We also review the documented association between single ductular units would provide a stronger evidence INK4a CC and p16 inactivation, and discuss a possible role for this for VMC to CC transformation. In

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Mar 1, 2015

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