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REVIEW ARTICLE Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases Vishwas Parekh, MD and Deniz Peker, MD Despite high prevalence of VMCs in population, Abstract: Benign developmental defects known as Von-Meyen- very few examples of malignant transformation of VMCs burg complexes (VMCs) have been postulated to progress to 7–25 to cholangiocarcinoma (CC) have been reported cholangiocarcinoma (CC) in rare instances. Although a gradual, (Table 1). Understandably, because of small number of sequential histologic transition from VMCs to CC has been cases to work with, most of these reports implicate VMCs described in some of these cases, the underlying genetic mech- in CC development through guilt-by-association rather anism is yet to be elucidated. Here, we review the literature to than cause and effect. Although simultaneity of VMCs put together a report on the clinicopathologic features and im- and CC in the same liver is suggestive of transition, munohistochemical changes associated with such trans- documenting such a transition to be taking place within formation. We also review the documented association between single ductular units would provide a stronger evidence INK4a CC and p16 inactivation, and discuss a possible role for this for VMC to CC transformation. In
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2015
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