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Maintaining Aim at a Moving Target

Maintaining Aim at a Moving Target COMMENTARY Frank C. Detterbeck, MD ung cancer accounts for as many cancer deaths as the next four leading causes Lcombined (breast, prostate, colon, and pancreas). Formerly a neglected disease, lung cancer has become a vibrant area of research. A literature search in Medline for “Lung Cancer” shows a dramatic increase in the number of publications (Figure 1). It was once possible to be an expert in lung cancer, but now at best, one can be an expert of a particular aspect. The rapid pace of new findings makes it difficult to stay abreast of even a highly focused particular aspect. The rapid advances and increasing focus on only pieces of the entire disease call for periodic reassessment of the “big picture.” Lung cancer has become a dynamic and fluid field, changing right before our eyes. This article examines changes we must keep in mind to avoid misinterpretation of new knowledge due to inappropriate comparisons. SOURCES OF CHANGE Stage Migration Stage migration occurs when a subgroup of patients is reassigned from a lower stage to a higher stage; simple mathematics shows that this results in better survival in both stages. Several recent articles have demonstrated a dramatic stage migration from http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Maintaining Aim at a Moving Target

Detterbeck, Frank C.
Journal of Thoracic Oncology , Volume 6 (3) – Mar 1, 2011
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ISSN
1556-0864
eISSN
1556-1380
DOI
10.1097/JTO.0b013e318207cda4
pmid
21317740
Publisher site
See Article on Publisher Site

Abstract

COMMENTARY Frank C. Detterbeck, MD ung cancer accounts for as many cancer deaths as the next four leading causes Lcombined (breast, prostate, colon, and pancreas). Formerly a neglected disease, lung cancer has become a vibrant area of research. A literature search in Medline for “Lung Cancer” shows a dramatic increase in the number of publications (Figure 1). It was once possible to be an expert in lung cancer, but now at best, one can be an expert of a particular aspect. The rapid pace of new findings makes it difficult to stay abreast of even a highly focused particular aspect. The rapid advances and increasing focus on only pieces of the entire disease call for periodic reassessment of the “big picture.” Lung cancer has become a dynamic and fluid field, changing right before our eyes. This article examines changes we must keep in mind to avoid misinterpretation of new knowledge due to inappropriate comparisons. SOURCES OF CHANGE Stage Migration Stage migration occurs when a subgroup of patients is reassigned from a lower stage to a higher stage; simple mathematics shows that this results in better survival in both stages. Several recent articles have demonstrated a dramatic stage migration from

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Mar 1, 2011

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