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Lymphocyte Antigen Abnormalities in Inflammatory Dermatoses

Lymphocyte Antigen Abnormalities in Inflammatory Dermatoses Lymphocyte antigen studies are frequently employed to confirm diagnoses of mycosis fungoides (MF). Antigenic abnormalities have been reported in other diseases that show some features of malignancy such as lymphomatoid papulosis, parapsoriasis en plaque and pityriasis lichenoides; however, the range of diseases in which these lymphocyte abnormalities may appear has not been fully described. We retrospectively examined histologic and immunoperoxidase (IPOX) data from the last 265 biopsies submitted to rule out MF. In 22 (8.3%) of the cases studied, IPOX demonstrated a lymphocyte surface antigen abnormality suggestive of MF without routine histologic evidence for the diagnosis. Twelve of these patients were subsequently found to have MF. The other 10 cases (3.8% of cases examined) provide the basis for this study. Three cases had lymphoproliferative disorders in which antigen abnormalities have been previously described: two cases were thought to be parapsoriasis, and there was a single case of lymphomatoid papulosis. The histologic diagnosis was dermal hypersensitivity reaction in three cases; psoriasis (n = 1), atopic dermatitis (n = 1), seborrheic dermatitis (n = 1), and annular elastolytic granuloma (n = 1). Lymphocyte surface antigen abnormalities have not been reported in tissue studies from these seven inflammatory dermatoses with no known malignant potential. It is important to recognize that lymphocyte surface markers can rarely be altered in benign reactive conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

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ISSN
1062-3345
eISSN
1533-4058

Abstract

Lymphocyte antigen studies are frequently employed to confirm diagnoses of mycosis fungoides (MF). Antigenic abnormalities have been reported in other diseases that show some features of malignancy such as lymphomatoid papulosis, parapsoriasis en plaque and pityriasis lichenoides; however, the range of diseases in which these lymphocyte abnormalities may appear has not been fully described. We retrospectively examined histologic and immunoperoxidase (IPOX) data from the last 265 biopsies submitted to rule out MF. In 22 (8.3%) of the cases studied, IPOX demonstrated a lymphocyte surface antigen abnormality suggestive of MF without routine histologic evidence for the diagnosis. Twelve of these patients were subsequently found to have MF. The other 10 cases (3.8% of cases examined) provide the basis for this study. Three cases had lymphoproliferative disorders in which antigen abnormalities have been previously described: two cases were thought to be parapsoriasis, and there was a single case of lymphomatoid papulosis. The histologic diagnosis was dermal hypersensitivity reaction in three cases; psoriasis (n = 1), atopic dermatitis (n = 1), seborrheic dermatitis (n = 1), and annular elastolytic granuloma (n = 1). Lymphocyte surface antigen abnormalities have not been reported in tissue studies from these seven inflammatory dermatoses with no known malignant potential. It is important to recognize that lymphocyte surface markers can rarely be altered in benign reactive conditions.

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 1995

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