Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Lymphocyte antigen studies are frequently employed to confirm diagnoses of mycosis fungoides (MF). Antigenic abnormalities have been reported in other diseases that show some features of malignancy such as lymphomatoid papulosis, parapsoriasis en plaque and pityriasis lichenoides; however, the range of diseases in which these lymphocyte abnormalities may appear has not been fully described. We retrospectively examined histologic and immunoperoxidase (IPOX) data from the last 265 biopsies submitted to rule out MF. In 22 (8.3%) of the cases studied, IPOX demonstrated a lymphocyte surface antigen abnormality suggestive of MF without routine histologic evidence for the diagnosis. Twelve of these patients were subsequently found to have MF. The other 10 cases (3.8% of cases examined) provide the basis for this study. Three cases had lymphoproliferative disorders in which antigen abnormalities have been previously described: two cases were thought to be parapsoriasis, and there was a single case of lymphomatoid papulosis. The histologic diagnosis was dermal hypersensitivity reaction in three cases; psoriasis (n = 1), atopic dermatitis (n = 1), seborrheic dermatitis (n = 1), and annular elastolytic granuloma (n = 1). Lymphocyte surface antigen abnormalities have not been reported in tissue studies from these seven inflammatory dermatoses with no known malignant potential. It is important to recognize that lymphocyte surface markers can rarely be altered in benign reactive conditions.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jan 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.