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Lymphangiogenesis and Podoplanin Expression in Oral Squamous Cell Carcinoma and the Associated Lymph Nodes

Lymphangiogenesis and Podoplanin Expression in Oral Squamous Cell Carcinoma and the Associated... RESEARCH ARTICLE Lymphangiogenesis and Podoplanin Expression in Oral Squamous Cell Carcinoma and the Associated Lymph Nodes Sı´lvia Ferreira de Sousa, DDS,* Frederico Omar Gleber-Netto, DDS,* Helenisa Helena de Oliveira-Neto, DDS, MSc,w Aline Carvalho Batista, DDS, PhD,w Mauro Henrique Nogueira Guimara˜es Abreu, DDS, PhD,z and Maria Ca´ssia Ferreira de Aguiar, DDS, PhD* the expression of podoplanin by more undifferentiated tumor Abstract: The objective of this study was to evaluate lym- cells suggests that this protein could be an indicator of tumor phangiogenesis in oral squamous cell carcinoma and in the as- aggressiveness. sociated lymph nodes and podoplanin expression in neoplastic Key Words: oral squamous cell carcinoma, lymphangiogenesis, cells at the invasive front. In addition, the association of the immunohistochemistry, podoplanin expression, lymph nodes. above parameters with lymph node metastasis was also inves- tigated. We used immunohistochemistry to examine primary (Appl Immunohistochem Mol Morphol 2012;20:588–594) tumors and lymph nodes, regardless of metastasis. Lymphatic vessel density (LVD) and microvessel density (MVD) were as- sessed by antibodies D2-40 and CD105, respectively, in intra- etastasis is the spread of cancer from its site of tumoral and peritumoral areas and in lymph node regions. Morigin and the subsequent colonization of distant Vascular endothelial growth factor-C http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Lymphangiogenesis and Podoplanin Expression in Oral Squamous Cell Carcinoma and the Associated Lymph Nodes

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Copyright
Copyright © 2012 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31824bb3ea
pmid
22495364
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Lymphangiogenesis and Podoplanin Expression in Oral Squamous Cell Carcinoma and the Associated Lymph Nodes Sı´lvia Ferreira de Sousa, DDS,* Frederico Omar Gleber-Netto, DDS,* Helenisa Helena de Oliveira-Neto, DDS, MSc,w Aline Carvalho Batista, DDS, PhD,w Mauro Henrique Nogueira Guimara˜es Abreu, DDS, PhD,z and Maria Ca´ssia Ferreira de Aguiar, DDS, PhD* the expression of podoplanin by more undifferentiated tumor Abstract: The objective of this study was to evaluate lym- cells suggests that this protein could be an indicator of tumor phangiogenesis in oral squamous cell carcinoma and in the as- aggressiveness. sociated lymph nodes and podoplanin expression in neoplastic Key Words: oral squamous cell carcinoma, lymphangiogenesis, cells at the invasive front. In addition, the association of the immunohistochemistry, podoplanin expression, lymph nodes. above parameters with lymph node metastasis was also inves- tigated. We used immunohistochemistry to examine primary (Appl Immunohistochem Mol Morphol 2012;20:588–594) tumors and lymph nodes, regardless of metastasis. Lymphatic vessel density (LVD) and microvessel density (MVD) were as- sessed by antibodies D2-40 and CD105, respectively, in intra- etastasis is the spread of cancer from its site of tumoral and peritumoral areas and in lymph node regions. Morigin and the subsequent colonization of distant Vascular endothelial growth factor-C

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Dec 1, 2012

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