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Lung cancer in persons with HIV

Lung cancer in persons with HIV Purpose of reviewLung cancer is emerging as a leading cause of death in HIV-infected persons. This review will discuss the latest scientific evidence regarding the mechanisms driving lung cancer risk in HIV infection, the clinical presentation of lung cancer in HIV-infected persons and recent data regarding the outcomes, treatment and prevention of lung cancer in this group.Recent findingsIncreased risk of lung cancer in HIV-infected persons is primarily due to higher smoking rates, but emerging evidence also implicates immunosuppression and inflammatory processes. Lung cancer outcomes may be worse in HIV-infected persons in the antiretroviral era, but this may stem, in part, from treatment disparities. Early detection of lung cancer using chest computed tomography (CT) is being increasingly adopted for smokers in the general population, and recent studies suggest that it may be safe and efficacious in HIV-infected smokers.SummaryLung cancer is an important complication associated with chronic HIV infection. It is associated with unique HIV-related causal mechanisms, and may be associated with worse outcomes in some HIV-infected persons. Smoking cessation and early cancer detection with chest CT are likely to benefit HIV-infected smokers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and AIDS Wolters Kluwer Health

Lung cancer in persons with HIV

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000326
pmid
27607596
Publisher site
See Article on Publisher Site

Abstract

Purpose of reviewLung cancer is emerging as a leading cause of death in HIV-infected persons. This review will discuss the latest scientific evidence regarding the mechanisms driving lung cancer risk in HIV infection, the clinical presentation of lung cancer in HIV-infected persons and recent data regarding the outcomes, treatment and prevention of lung cancer in this group.Recent findingsIncreased risk of lung cancer in HIV-infected persons is primarily due to higher smoking rates, but emerging evidence also implicates immunosuppression and inflammatory processes. Lung cancer outcomes may be worse in HIV-infected persons in the antiretroviral era, but this may stem, in part, from treatment disparities. Early detection of lung cancer using chest computed tomography (CT) is being increasingly adopted for smokers in the general population, and recent studies suggest that it may be safe and efficacious in HIV-infected smokers.SummaryLung cancer is an important complication associated with chronic HIV infection. It is associated with unique HIV-related causal mechanisms, and may be associated with worse outcomes in some HIV-infected persons. Smoking cessation and early cancer detection with chest CT are likely to benefit HIV-infected smokers.

Journal

Current Opinion in HIV and AIDS – Wolters Kluwer Health

Published: Jan 1, 2017

References

  • Cancer burden in the HIV-infected population in the United States
  • Epidemic of lung cancer in patients with HIV infection
  • Causes of death among HIV-infected patients in France in 2010 (national survey): trends since
  • HIV as an independent risk factor for incident lung cancer
  • Lung cancer incidence and mortality among HIV-infected and HIV-uninfected injection drug users
  • Cumulative incidence of cancer among persons with HIV in North America: a cohort study
  • Lung cancer incidence and survival among HIV-infected and uninfected women and men
  • Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012
  • Incidence of non-AIDS-defining malignancies in HIV-infected versus noninfected patients in the HAART era: impact of immunosuppression
  • Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection
  • HIV infection is associated with an increased risk for lung cancer, independent of smoking
  • Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study
  • Excess cancers among HIV-infected people in the United States
  • Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis
  • Long-term cigarette smoking trajectories among HIV-seropositive and seronegative MSM in the multicenter AIDS cohort study
  • Prevalence and correlates of smoking and readiness to quit smoking in people living with HIV in Austria and Germany
  • Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
  • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
  • Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans
  • Increased susceptibility to pulmonary emphysema among HIV-seropositive smokers
  • Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection
  • Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study Group
  • Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients
  • Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden, development of airspace enlargement, and pulmonary inflammation in mice
  • Human immunodeficiency virus infection as a prognostic factor in surgical patients with nonsmall cell lung cancer
  • Risk of non-AIDS-defining cancers among HIV-1-infected individuals in France between 1997 and 2009: results from a French cohort
  • CD4 measures as predictors of lung cancer risk and prognosis in HIV infection. Conference on Retroviruses and Opportunistic Infections
  • Pulmonary infections and risk of lung cancer among persons with AIDS
  • HIV impairs lung epithelial integrity and enters the epithelium to promote chronic lung inflammation
  • Multicenter comparison of lung and oral microbiomes of HIV-infected and HIV-uninfected individuals
  • Effect of advanced HIV infection on the respiratory microbiome
  • Effects of smoking on non-AIDS-related morbidity in HIV-infected patients
  • Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers
  • The complexity of HIV persistence and pathogenesis in the lung under antiretroviral therapy: challenges beyond AIDS
  • Healthy HIV-1-infected individuals on highly active antiretroviral therapy harbor HIV-1 in their alveolar macrophages
  • Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene
  • Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells
  • Impact of HIV on lung tumorigenesis in an animal model
  • Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study
  • Cancer risk and use of protease inhibitor or nonnucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy: the D: A: D study
  • Protease inhibitors exposure is not related to lung cancer risk in HIV smoker patients: a nested case-control study
  • Prognosis in HIV infected patients with non-small cell lung cancer. 20th Conference on Retroviruses and Opportunistic Infections
  • Survival among HIV-infected and HIV-uninfected individuals with common non-AIDS-defining cancers
  • EGFR and KRAS mutation status in nonsmall-cell lung cancer occurring in HIV-infected patients
  • Underrepresentation of patients 65 years of age or older in cancer-treatment trials
  • Predictors of enrollment in lung cancer clinical trials
  • Enrollment of African Americans onto clinical treatment trials: study design barriers
  • Thirty-day postoperative mortality among individuals with HIV infection receiving antiretroviral therapy and procedure-matched, uninfected comparators
  • Human immunodeficiency virus infection and nonsmall cell lung cancer: survival and toxicity of antineoplastic chemotherapy in a cohort study
  • Lung cancer in HIV positive patients: the GICAT experience
  • Disparities in cancer treatment among patients infected with the human immunodeficiency virus
  • Cancer treatment disparities in HIV-infected individuals in the United States
  • Do HIV-infected nonsmall cell lung cancer patients receive guidance-concordant care?
  • Disparities in the treatment and outcomes of lung cancer among HIV-infected individuals
  • Among HIV-infected patients in the United States
  • Trends in survival after cancer diagnosis among HIV-infected individuals between 1992 and 2009. Results from the FHDH-ANRS CO4 cohort
  • Survival in HIV-infected patients after a cancer diagnosis in the cART Era: results of an italian multicenter study
  • Non-AIDS defining cancers in the D:A:D Study: time trends and predictors of survival – a cohort study
  • HIV-associated lung cancer: survival in an unselected cohort
  • Human immunodeficiency virus-associated lung cancer in the era of highly active antiretroviral therapy
  • Lung cancer, a new challenge in the HIV-infected population
  • Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study
  • Feasibility and preliminary efficacy of a web-based smoking cessation intervention for HIV-infected smokers: a randomized controlled trial
  • A test of motivational plus nicotine replacement interventions for HIV positive smokers
  • A randomized controlled trial of a tailored group smoking cessation intervention for HIV-infected smokers
  • Behavioral interventions for tobacco use in HIV-infected smokers: a meta-analysis
  • An algorithm approach to determining smoking cessation treatment for persons living with HIV/AIDS: results of a pilot trial
  • Safety of varenicline among smokers enrolled in the lung HIV study
  • Motivation and patch treatment for HIV+ smokers: a randomized controlled trial
  • Reduced lung-cancer mortality with low-dose computed tomographic screening
  • Clinically significant incidental findings among human immunodeficiency virus-infected men during computed tomography for determination of coronary artery calcium
  • Findings in asymptomatic HIV-infected patients undergoing chest computed tomography testing: implications for lung cancer screening
  • Prospective CT screening for lung cancer in a high-risk population: HIV-positive smokers
  • Feasibility and efficacy of early lung cancer diagnosis with chest computed tomography in HIV-infected smokers
  • Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial